sickle cell
Curved blood cells
Sickle cell refers to a hereditary blood disorder in which red blood cells become rigid and crescent-shaped, obstructing blood flow and causing pain, anemia, and organ damage.
The condition predominantly affects people of African, Mediterranean, and South Asian descent.
She has sickle cell disease.
Sickle cell trait describes carrying one copy of the gene without full symptoms.
Bodily or emotional distress
- crisisDecisive dangerous moment
- fatigueWeariness from prolonged exertion
- jaundiceYellowing from bile pigment
- shortness of breathDifficulty inhaling enough air
ulcers · stroke · infections · vision problems · gallstones · chronic pain · priapism · retinopathy
Erythrocyte's oxygen-binding protein
- erythrocyteOxygen-transporting blood component
- hemolysisRed blood cell destruction
- transfusionTransfer of blood intravenously
- hematologyScience of blood disorders
oxygenation · anemia · blood count · polymerization · deoxygenation · blood smear · bilirubin
Property received from ancestors
- carrierOne that transports
- traitDistinguishing personal quality
- mutationPermanent DNA alteration
- alleleGene variant at one locus
genotype · phenotype · genetic testing · newborn screening · family history · pedigree · heterozygous · homozygous
Infusing healthy hematopoietic cells
- folic acidB-vitamin preventing birth defects
- blood transfusionInfusing donated cells intravenously
- pain managementReducing patient suffering medically
- gene therapyMedical DNA modification treatment
pain
Bodily or emotional distress
- crisisDecisive dangerous moment
- fatigueWeariness from prolonged exertion
- jaundiceYellowing from bile pigment
shortness of breath · ulcers · stroke · infections · vision problems · gallstones · chronic pain · priapism · retinopathy · organ damage
hemoglobin
Erythrocyte's oxygen-binding protein
- erythrocyteOxygen-transporting blood component
- hemolysisRed blood cell destruction
- transfusionTransfer of blood intravenously
hematology · oxygenation · anemia · blood count · polymerization · deoxygenation · blood smear · bilirubin
inheritance
Property received from ancestors
allele · genotype · phenotype · genetic testing · newborn screening · family history · pedigree · heterozygous · homozygous · genetic counseling
bone marrow transplant
Infusing healthy hematopoietic cells
- folic acidB-vitamin preventing birth defects
- blood transfusionInfusing donated cells intravenously
- pain managementReducing patient suffering medically
gene therapy · hydration · oxygen therapy · CRISPR · clinical trials
- hematologyblood smear, bone marrow, bone marrow biopsy, leukemia, lymphoma
- Genetic SyndromesDown syndrome, fragile X syndrome, DiGeorge syndrome, BRCA1, neurofibromatosis
- diseasescancer, diabetes, tuberculosis, influenza, measles
- chronic conditionsdiabetes, heart disease, asthma, arthritis, hypertension
- Blood Systemblood, platelets, hematopoiesis, bone marrow, red marrow
- Anemiairon deficiency, hemoglobin, low hemoglobin, low iron, pernicious anemia