BRCA1
Breast cancer gene
BRCA1 is a human gene that produces a protein involved in repairing damaged DNA and suppressing tumor growth.
Mutations in this gene significantly increase the risk of breast and ovarian cancers, which is why genetic testing for BRCA1 variants has become an important tool in cancer prevention.
The name stands for BReast CAncer gene 1.
She tested positive for a BRCA1 mutation and is considering preventive surgery.
Differing form of something
- pathogenicCausing disease
- deleteriousCausing harm or damage
- germlineHereditary cellular lineage
- somaticConcerning the body
frameshift · nonsense · truncation · polymorphism · penetrance · haploinsufficiency · Ashkenazi · rearrangement
Gene preventing uncontrolled growth
- DNA repairRestoring damaged genetic code
- double-strand breakComplete DNA backbone cleavage
- nucleotideGenetic code subunit
- transcriptionWritten version of speech
gene expression · cell cycle · locus · allele · genotype · oncogene · polymerase · splicing
Analysis for inherited disorders
- screeningEvaluative selection process
- mammogramBreast tissue X-ray
- MRIMagnetic body imaging
- ultrasoundInaudible high-frequency waves
biopsy · pathology · sequencing · direct-to-consumer · counselor · informed consent
Property received from ancestors
- family historyRecord of ancestors
- pedigreeRecord of descent
- predispositionInnate tendency toward something
- carrierOne that transports
risk assessment · genetic counseling · genetic testing · ancestry · lineage · kindred · presymptomatic · familial
Malignancy of egg-producing glands
- mastectomySurgical breast removal
- oncologistPhysician specializing in tumors
- chemotherapyAnti-cancer drug treatment
- tumorAbnormal tissue mass
malignant · metastasis · prognosis · surveillance · tamoxifen · Angelina Jolie
Controlled health research experiments
- genome sequencingReading complete DNA sequence
- CRISPRGene-editing molecular machinery
- gene therapyMedical DNA modification treatment
- targeted therapyTreatment hitting specific molecules
biomarker · bioinformatics · cell line · knockdown · NIH · peer review
variant
Differing form of something
- pathogenicCausing disease
- deleteriousCausing harm or damage
- germlineHereditary cellular lineage
somatic · frameshift · nonsense · truncation · polymorphism · penetrance · haploinsufficiency · Ashkenazi · rearrangement · deletion
tumor suppressor
Gene preventing uncontrolled growth
- DNA repairRestoring damaged genetic code
- double-strand breakComplete DNA backbone cleavage
- nucleotideGenetic code subunit
transcription · gene expression · cell cycle · locus · allele · genotype · oncogene · polymerase · splicing · ATM
genetic testing
Analysis for inherited disorders
ultrasound · biopsy · pathology · sequencing · direct-to-consumer · counselor · informed consent
inheritance
Property received from ancestors
- family historyRecord of ancestors
- pedigreeRecord of descent
- predispositionInnate tendency toward something
carrier · risk assessment · genetic counseling · genetic testing · ancestry · lineage · kindred · presymptomatic · familial
ovarian cancer
Malignancy of egg-producing glands
- mastectomySurgical breast removal
- oncologistPhysician specializing in tumors
- chemotherapyAnti-cancer drug treatment
tumor · malignant · metastasis · prognosis · surveillance · tamoxifen · Angelina Jolie
clinical trials
Controlled health research experiments
- genome sequencingReading complete DNA sequence
- CRISPRGene-editing molecular machinery
- gene therapyMedical DNA modification treatment
targeted therapy · biomarker · bioinformatics · cell line · knockdown · NIH · peer review