carcinogenesis
Malignancy's biological origin
Carcinogenesis is the process by which normal cells transform into cancer cells.
The term covers the entire sequence—from initial genetic damage through uncontrolled cell division to tumor formation.
Substances or factors that trigger this process are carcinogens: Studies linked the chemical to carcinogenesis in laboratory animals.
Also called oncogenesis or tumorigenesis.
Formal admission ceremony
- promotionRank increase or publicity
- progressionSequential forward movement
- transformationThorough change in form
- neoplasiaAbnormal tissue proliferation
hyperplasia · dysplasia · metastasis · angiogenesis · invasion · proliferation · adenoma · latency period
Parent splitting into offspring
- proliferationRapid increase in quantity
- immortalizationMaking something last forever
- mitosisNuclear division producing identical cells
- DNA polymeraseEnzyme that copies chromosomes
Alterations in genetic sequence
- DNA damageInjury to genetic material
- mutagenesisInducing stable genetic changes
- epigeneticsHeritable expression changes, sequence intact
- gene expressionDNA to functional product
BRCA1 · cell cycle · apoptosis · DNA repair · methylation · growth factors
Fibrous fireproofing mineral
- benzeneAromatic hydrocarbon solvent
- tobacco smokeCombusted leaf vapor
- formaldehydeColorless pungent preservative gas
- vinyl chlorideToxic PVC monomer
arsenic · dioxins · nitrosamines · acrylamide · radon · UV radiation · ionizing radiation · heavy metals
Species used in research
- cell linesPropagated cellular populations
- in vitroIn an artificial environment
- in vivoWithin living tissue
- bioassayTest using living tissue
initiation
Formal admission ceremony
- promotionRank increase or publicity
- progressionSequential forward movement
- transformationThorough change in form
neoplasia · hyperplasia · dysplasia · metastasis · angiogenesis · invasion · proliferation · adenoma · latency period
cell division
Parent splitting into offspring
- proliferationRapid increase in quantity
- immortalizationMaking something last forever
- mitosisNuclear division producing identical cells
mutations
Alterations in genetic sequence
- DNA damageInjury to genetic material
- mutagenesisInducing stable genetic changes
- epigeneticsHeritable expression changes, sequence intact
gene expression · BRCA1 · cell cycle · apoptosis · DNA repair · methylation · growth factors
asbestos
Fibrous fireproofing mineral
- benzeneAromatic hydrocarbon solvent
- tobacco smokeCombusted leaf vapor
- formaldehydeColorless pungent preservative gas
vinyl chloride · arsenic · dioxins · nitrosamines · acrylamide · radon · UV radiation · ionizing radiation · heavy metals · pesticides
animal models
Species used in research
- cell linesPropagated cellular populations
- in vitroIn an artificial environment
- in vivoWithin living tissue
- oncologytumor, carcinoma, metastasis, malignancy, tumor suppressor
- Cancer Biologymalignant cells, metastasis, tumor growth, melanoma, basal cell carcinoma
- Cancer GenomicsBRCA, tumor markers, tumor suppressor, point mutation, mutations
- pathologydisease, infection, tumor, lesion, lesions
- radiobiologyradiobiology, DNA damage, mutations, ionizing radiation, cell damage
- toxicologytoxicology, poison, toxin, venom, toxicity
carcinogenesisapoptosis
Programmed cell death
chemoprevention · senescence · autophagy · cancer prevention · homeostasis
carcinogenesistissue repair
Biological wound healing process
wound healing · regeneration · benign growth · organogenesis · health maintenance
cancer, genesis, carcinogen, carcinogenic, oncogene, carcinogens, oncogenes, carcinogenicity