apoptosis

Programmed cellular demise

Apoptosis is programmed cell death—a controlled process by which cells systematically dismantle themselves when they're damaged, infected, or no longer needed.

Unlike necrosis, where cells die messily from injury, apoptosis is orderly: the cell shrinks, fragments, and gets absorbed without triggering inflammation.

The process is essential for normal development and health: Apoptosis shapes fingers by eliminating the webbing between them.

Cancer often involves cells that evade apoptosis.

mechanism

cytochrome

Heme protein transferring electrons

phagocytosis · executioner · shrinkage · fragmentation

pathways

intrinsic

Belonging by nature

versus

necrosis

Localized cell death

inflammation

disease

cancer

Uncontrolled cell proliferation disease

oncology · neurodegeneration · autoimmunity · leukemia · lymphoma · carcinogenesis · metastasis · evasion · defective · dysregulation

regulation

homeostasis

Biological internal stability maintenance

IAPs · phosphorylation · transcription · upregulation · downregulation · checkpoint · balance · suppression · modulation · feedback

aging

senescence

Gradual functional decline with age

age-related · regeneration

development

morphogenesis

Developmental shape emergence

programmed · remodeling · homeostatic

Categories
Opposites
cell death mechanism

apoptosisnecrosis

Localized cell death

autolysis

cellular fate

apoptosismitosis

Nuclear division producing identical cells

cell division · cell growth · cytokinesis · hyperplasia

growth regulation

apoptosisimmortalization

Making something last forever

hyperplasia · neoplasia · cancer · carcinogenesis

Family

ptosis, apoptotic

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