bioassay
Organism-based potency test
A bioassay is a test that measures the potency or effect of a substance by observing its impact on living organisms or biological tissue.
Researchers use bioassays to determine drug concentrations, detect toxins, or assess environmental contamination: The bioassay revealed elevated hormone levels in the water sample.
The method relies on biological response rather than purely chemical analysis.
Prescribed conduct rules
- screeningEvaluative selection process
- validationConfirming truth or accuracy
- controlsOperates or regulates
- replicatesCopies precisely
precision · accuracy · reproducibility · standardization · blank · incubation · reagents · automation
Relationship between amount and effect
- potencyDegree of strength
- efficacyAbility to produce results
- agonistReceptor-binding trigger molecule
- antagonistOne who opposes another
ligand · bioavailability · affinity · selectivity · pharmacokinetics · modulator · activity
Sustained single-minded attention
- titrationMeasuring concentration by addition
- spectrophotometryMeasuring light wavelength absorption
- luminescenceHeatless light emission
- absorbanceLight uptake measurement
signal · sensitivity · specificity · units · endpoint · colorimetric
Microscopic living entities
- enzymesReaction-speeding proteins
- antibodiesProteins targeting pathogens
- proteinsAmino acid polymers
- bacteriaNucleus-free single-celled organisms
viruses · fungi · pathogens · receptors · hormones · cytotoxicity · cultivation · biochemical
Half-fatal dose measurement
- cytotoxicToxic to cells
- mutagenicCausing permanent DNA changes
- carcinogenicCauses cancer
- neurotoxicDamaging to nervous system
protocol
Prescribed conduct rules
- screeningEvaluative selection process
- validationConfirming truth or accuracy
- controlsOperates or regulates
replicates · precision · accuracy · reproducibility · standardization · blank · incubation · reagents · automation
dose-response
Relationship between amount and effect
antagonist · ligand · bioavailability · affinity · selectivity · pharmacokinetics · modulator · activity
concentration
Sustained single-minded attention
- titrationMeasuring concentration by addition
- spectrophotometryMeasuring light wavelength absorption
- luminescenceHeatless light emission
absorbance · signal · sensitivity · specificity · units · endpoint · colorimetric
microorganisms
Microscopic living entities
- enzymesReaction-speeding proteins
- antibodiesProteins targeting pathogens
- proteinsAmino acid polymers
bacteria · viruses · fungi · pathogens · receptors · hormones · cytotoxicity · cultivation · biochemical · genomics
LD50
Half-fatal dose measurement
- cytotoxicToxic to cells
- mutagenicCausing permanent DNA changes
- carcinogenicCauses cancer
neurotoxic · hepatotoxic · nephrotoxic · threshold · teratogenic
bioassayspectroscopy
Study of light-matter interaction
chemical analysis · chromatography · mass spectrometry · titration · electrophoresis
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