tumor suppressor
Growth-limiting gene
A tumor suppressor is a gene that normally restrains cell division or promotes cell death, preventing uncontrolled growth.
When tumor suppressors are damaged or inactivated through mutation, cells can proliferate unchecked, potentially leading to cancer.
The p53 gene is the most studied tumor suppressor: Mutations in tumor suppressor genes are found in most cancers.
- apoptosisProgrammed cell death
- DNA repairRestoring damaged genetic code
- cancer preventionReducing malignancy risk
- mutationPermanent DNA alteration
- wild typeNatural, unmutated genetic variant
cancer · BRCA1 · gatekeeper · gene expression · senescence · protein · cell cycle · checkpoint · metastasis · pathway · growth · suppression · DNA · brake · regulation · proliferation · loss · watchdog
- oncologycancer, carcinoma, metastasis, malignancy, oncogene
- Cancer GenomicsBRCA, carcinogenesis, point mutation, mutations, mutation
- Genesallele, oncogene, transgene, dominant gene, recessive gene
- DNA Proteinshistone, histones, repressor, repressors, activator
- cell signalingreceptor, ligand, receptors, signaling, kinase
- Hedgehog Pathway
cancer-promoting vs cancer-inhibiting function
tumor suppressoroncogene
Tumor-inducing genetic element
cancer gene · HER2 · BCR-ABL