dose-response
Amount determines outcome
Dose-response describes the relationship between the amount of a substance and its effect on a biological system.
In pharmacology and toxicology, dose-response curves show how outcomes change as doses increase: The dose-response data showed the drug was effective at 10mg but toxic at 50mg.
The principle underlies drug development, safety testing, and the maxim that "the dose makes the poison."
Point of beginning
- efficacyAbility to produce results
- potencyDegree of strength
- LD50Half-fatal dose measurement
- toxicityCapacity to cause harm
therapeutic · bioavailability · saturation · receptor · binding · affinity · antagonist · agonist
Harmful ingested substance
- exposureState of being unprotected
- carcinogenCancer-promoting agent
- mutagenAgent causing genetic change
- teratogenDevelopmental toxin
safety · margin · risk · assessment · hazard · contamination · environmental · occupational
Curving in two directions
- linearArranged in straight succession
- biphasicHaving two distinct stages
- plateauFlat highland area
- slopeAngled terrain or steepness
asymptote · inflection · gradient · logarithmic · exponential · nonlinear · J-shaped · U-shaped
Systematic investigation procedure
- clinicalEmotionally detached, medically precise
- trialJudicial examination of claims
- controlAuthority to direct
- placeboInactive therapeutic substitute
variable · measurement · quantification · calibration · standardization · replication · validity · correlation
threshold
Point of beginning
toxicity · therapeutic · bioavailability · saturation · receptor · binding · affinity · antagonist · agonist · titration
poison
Harmful ingested substance
- exposureState of being unprotected
- carcinogenCancer-promoting agent
- mutagenAgent causing genetic change
teratogen · safety · margin · risk · assessment · hazard · contamination · environmental · occupational · acute
sigmoid
Curving in two directions
slope · asymptote · inflection · gradient · logarithmic · exponential · nonlinear · J-shaped · U-shaped · monotonic
experiment
Systematic investigation procedure
- clinicalEmotionally detached, medically precise
- trialJudicial examination of claims
- controlAuthority to direct
placebo · variable · measurement · quantification · calibration · standardization · replication · validity · correlation · causation
- pharmacologypharmacology, drugs, pharmacokinetics, drug, medications
- toxicologytoxicology, poison, toxin, venom, toxicity
- dosingoverdose, microdosing, microdose, megadose, booster
- drug researchdrug discovery, drug testing, drug screening, drug approval, clinical trials
- Ecotoxicologytoxicology, bioassay, LD50, exposure assessment, sentinel species
- risk assessmentrisk factors, risk mitigation, exposure assessment, relative risk, health risk