COX-2
Prostaglandin-producing protein
COX-2 is an enzyme (cyclooxygenase-2) that the body produces in response to inflammation, injury, or pain.
Unlike its counterpart COX-1, which maintains normal bodily functions like protecting the stomach lining, COX-2 is primarily associated with inflammatory responses.
Drugs that selectively inhibit COX-2, such as celecoxib, are designed to reduce pain and inflammation while minimizing gastrointestinal side effects common with traditional anti-inflammatory medications.
Protein that hastens reactions
- prostaglandinLipid compound affecting inflammation
- catalysisAccelerating reactions without consumption
- oxidationLosing electrons chemically
- peroxidasePeroxide-degrading enzyme
fatty acid · metabolism · substrate · active site · inducible · constitutive · biosynthesis · lipid
Agent that slows reactions
- NSAIDNon-steroidal anti-inflammatory drug
- selectiveChoosing with care
- aspirinAcetylsalicylic acid tablet
- ibuprofenAnti-inflammatory pain reliever
naproxen · diclofenac · analgesic · anti-inflammatory · antipyretic · therapeutic · dosage · bioavailability
Tending to provoke outrage
- cytokinesImmune signaling proteins
- swellingAbnormal tissue enlargement
- painBodily or emotional distress
- rednessCrimson-hued state
fever · immune response · interleukin · macrophage · arthritis · tissue damage · edema · acute
Blocked blood to muscle
- strokeSudden brain blood blockage
- thrombosisClot forming in vessel
- plateletBlood's clotting fragment
- blood clotCoagulated mass in vessels
myocardial infarction · cardiovascular risk · hypertension · atherosclerosis · endothelial · vascular · cardiac · ischemia
Uncontrolled cell proliferation disease
- tumorAbnormal tissue mass
- carcinogenesisMalignant transformation process
- colorectalOf the large intestine
- breast cancerMalignant growth in mammary glands
prostate cancer · lung cancer · chemoprevention · apoptosis · angiogenesis · metastasis · proliferation · neoplasia
enzyme
Protein that hastens reactions
- prostaglandinLipid compound affecting inflammation
- catalysisAccelerating reactions without consumption
- oxidationLosing electrons chemically
peroxidase · fatty acid · metabolism · substrate · active site · inducible · constitutive · biosynthesis · lipid · membrane
inhibitor
Agent that slows reactions
- NSAIDNon-steroidal anti-inflammatory drug
- selectiveChoosing with care
- aspirinAcetylsalicylic acid tablet
ibuprofen · naproxen · diclofenac · analgesic · anti-inflammatory · antipyretic · therapeutic · dosage · bioavailability · half-life
inflammatory
Tending to provoke outrage
- cytokinesImmune signaling proteins
- swellingAbnormal tissue enlargement
- painBodily or emotional distress
redness · fever · immune response · interleukin · macrophage · arthritis · tissue damage · edema · acute · chronic
heart attack
Blocked blood to muscle
- strokeSudden brain blood blockage
- thrombosisClot forming in vessel
- plateletBlood's clotting fragment
blood clot · myocardial infarction · cardiovascular risk · hypertension · atherosclerosis · endothelial · vascular · cardiac · ischemia · arrhythmia
cancer
Uncontrolled cell proliferation disease
- tumorAbnormal tissue mass
- carcinogenesisMalignant transformation process
- colorectalOf the large intestine
breast cancer · prostate cancer · lung cancer · chemoprevention · apoptosis · angiogenesis · metastasis · proliferation · neoplasia · polyp
- COX-2 inhibitors
- enzymeslipase, amylase, protease, kinase, enzyme
- Oxidoreductasesoxidase, peroxidase, catalase, CYP450, CYP2D6
- Immune Moleculesantibody, antigens, complement, interleukins, complement proteins