active site
Catalytic binding region
The active site is the specific region on an enzyme where a substrate binds and a chemical reaction occurs.
Like a lock receiving a key, the active site's three-dimensional shape determines which molecules can interact with it: The drug works by blocking the enzyme's active site.
The term appears primarily in biochemistry and molecular biology.
- induced fitEnzyme conforms to substrate
- substrateUnderlying supporting material
- catalysisAccelerating reactions without consumption
- enzymeProtein that hastens reactions
- lock and keyPaired fastening mechanism
cleft · pocket · biochemistry · cofactor · inhibitor · hydrolysis · docking · protein · activation energy · receptor · key · molecular · Michaelis-Menten · mechanism · groove · turnover · protein folding · amino acids
- biochemistryenzymes, proteins, biochemistry, protein, enzyme
- drug discoverycompounds, SAR, scaffolds, inhibitors, agonists
- Enzymologysubstrate, catalysis, Michaelis-Menten, turnover number, inhibitor
- Protein Engineeringprotein folding, mutagenesis, scaffold, Rosetta
- protein structurefolding, conformation, domain, motif, fold
- structural biologyelectron microscopy, protein folding, electron diffraction, Rosetta, docking