complement proteins
Blood defense cascade
Complement proteins are a group of proteins in the blood that work together to destroy pathogens and trigger inflammation.
They "complement" the immune system's antibodies by forming attack complexes that puncture bacterial cell walls or mark invaders for destruction by other immune cells.
The patient's complement proteins were depleted after the infection.
function
Cell membrane rupture
- chemotaxisMovement toward chemical cues
- inflammationProtective tissue response
- phagocytosisCellular ingestion of particles
- cell lysisCell membrane destruction
biochemistry
Blood's watery portion
- proteaseProtein-cleaving enzyme
- zymogenInactive enzyme precursor
- cleavageTendency to split cleanly
- glycoproteinProtein bonded to carbohydrates
enzymatic · precursor · substrate · cofactor · domain · synthesis
disease
Lack of something needed
- autoimmunityImmune system targets self
- lupusChronic autoimmune disorder
- sepsisDangerous inflammatory infection response
lysis
Cell membrane rupture
- chemotaxisMovement toward chemical cues
- inflammationProtective tissue response
- phagocytosisCellular ingestion of particles
serum
Blood's watery portion
glycoprotein · enzymatic · precursor · substrate · cofactor · domain · synthesis
deficiency
Lack of something needed
- autoimmunityImmune system targets self
- lupusChronic autoimmune disorder
- sepsisDangerous inflammatory infection response
C3
Third neck vertebra
- proteinsproteins, albumin, collagen, casein, keratin
- Complement SystemC3, C3b, C4, MAC
- biologicsbiologics, biologicals, biopharmaceuticals, monoclonal antibodies, monoclonal antibody
- blood proteinsalbumin, globulin, globulins, fibrinogen, immunoglobulin
- Immune Moleculesantibody, antigens, interleukins, toll-like receptors, C3
- immunityimmune, immunity, immune system, immune response, immune cells