sclerosis
Pathological tissue stiffening
Sclerosis is the abnormal hardening of body tissue, especially from overgrowth of fibrous tissue or deposits.
In medicine, it appears in conditions like arteriosclerosis (hardening of arteries) and multiple sclerosis (hardening of nerve tissue).
Figuratively, sclerosis describes institutional rigidity—systems that have become inflexible and resistant to change: The company suffered from organizational sclerosis.
Mineral hardening of tissue
- indurationAbnormal tissue firmness
- stiffeningBecoming less pliable
- ossificationConversion to bone tissue
- thickeningIncreasing in density
arterial · plaque buildup · narrowing · rigidity · fibrotic · scarring · densification · vascular
Pathological connective tissue buildup
- collagenStructural body protein
- scarringPermanent mark formation
- granulationMaking into small grains
- fibroblastsCollagen-producing connective tissue cells
remodeling · interstitial · contracture · cicatrix · glial · astrocytes · connective tissue
Nerve sheath degradation
- lesionsAreas of damaged tissue
- relapsing-remittingRecurring then temporarily resolving
- autoimmuneBody attacks itself
- neurologicalOf the nervous system
spasticity · fatigue · MRI · remission · relapse · white matter · myelin sheath · cerebrospinal
Motor neuron disease
- Lou Gehrig's diseaseDegenerative motor neuron condition
- motor neuronNerve cell activating muscles
- progressiveFavoring reform and innovation
- atrophyWasting from disuse
neurodegeneration · lateral · tuberous · hippocampal · systemic
Immune response protein
- corticosteroidsInflammation-suppressing steroid medications
- immunomodulatorsAgents modifying bodily defenses
- disease-modifyingAlters underlying condition
- rehabilitationRecovery from injury/addiction
calcification
Mineral hardening of tissue
- indurationAbnormal tissue firmness
- stiffeningBecoming less pliable
- ossificationConversion to bone tissue
thickening · arterial · plaque buildup · narrowing · rigidity · fibrotic · scarring · densification · vascular · aortic
fibrosis
Pathological connective tissue buildup
- collagenStructural body protein
- scarringPermanent mark formation
- granulationMaking into small grains
fibroblasts · remodeling · interstitial · contracture · cicatrix · glial · astrocytes · connective tissue
demyelination
Nerve sheath degradation
- lesionsAreas of damaged tissue
- relapsing-remittingRecurring then temporarily resolving
- autoimmuneBody attacks itself
neurological · spasticity · fatigue · MRI · remission · relapse · white matter · myelin sheath · cerebrospinal · disability
ALS
Motor neuron disease
- Lou Gehrig's diseaseDegenerative motor neuron condition
- motor neuronNerve cell activating muscles
- progressiveFavoring reform and innovation
atrophy · neurodegeneration · lateral · tuberous · hippocampal · systemic
interferon
Immune response protein
- corticosteroidsInflammation-suppressing steroid medications
- immunomodulatorsAgents modifying bodily defenses
- disease-modifyingAlters underlying condition
- ailmentsache, aches, ailment, cold, flu
- hardeninghardening, stiffening, solidification, solidifying, rigidifying
- Neurological Disordersepilepsy, Parkinson's, Alzheimer's, neuropathy, dementia
- pathologycancer, disease, infection, tumor, lesion
- brain pathologyneurodegeneration, demyelination, atrophy, lesion, necrosis
- Skin Findingslesion, macule, papule, pustule, vesicle
sclerosismalacia
Morbid tissue softening
softening · elasticity · pliability · suppleness · flexibility
sclerosisregeneration
Biological self-repair process
healing · restoration · vitality · resilience · patency
sclerosisflexibility
Ability to adapt easily
adaptability · dynamism · fluidity · plasticity · renewal
- multiple sclerosisAutoimmune demyelinating neurological disease
- tuberous sclerosisGenetic disorder causing noncancerous growths