deubiquitinase
A deubiquitinase is an enzyme that removes ubiquitin—a small regulatory protein—from other proteins.
This reverses the tagging process that marks proteins for degradation or alters their function.
Deubiquitinases help regulate protein turnover, cell signaling, and DNA repair: Mutations in deubiquitinases have been linked to various cancers.
Protein-cleaving enzyme
- hydrolaseEnzyme cleaving via water
- cleavageTendency to split cleanly
- substrateUnderlying supporting material
- catalysisAccelerating reactions without consumption
active site · cysteine · USP · specificity · chain · linkage · linear · thiol
Decline in condition
- homeostasisBiological internal stability maintenance
- quality controlMaintaining production standards
- recyclingReprocessing used materials
- salvageRecovering damaged goods
autophagy · lysosome · regulation · stability · half-life
Protective tissue response
- immune responseBody fighting foreign threats
- interferonImmune response protein
- DNA damageInjury to genetic material
- BRCA1Tumor suppressor gene
Uncontrolled cell proliferation disease
- neurodegenerationProgressive loss of neurons
- ParkinsonSurname behind tremors
- ataxiaImpaired voluntary movement control
- inhibitorAgent that slows reactions
oncogene · tumor suppressor · mutation · dysfunction · drug discovery · biomarker
Area of control
- coiled-coilHelices twisted together
- crystal structureOrdered atomic arrangement in solids
- binding siteMolecular attachment region
- recognitionPerceiving something as known
protease
Protein-cleaving enzyme
- hydrolaseEnzyme cleaving via water
- cleavageTendency to split cleanly
- substrateUnderlying supporting material
catalysis · active site · cysteine · USP · specificity · chain · linkage · linear · thiol
degradation
Decline in condition
- homeostasisBiological internal stability maintenance
- quality controlMaintaining production standards
- recyclingReprocessing used materials
salvage · autophagy · lysosome · regulation · stability · half-life
inflammation
Protective tissue response
- immune responseBody fighting foreign threats
- interferonImmune response protein
- DNA damageInjury to genetic material
BRCA1 · receptor · endocytosis · trafficking
cancer
Uncontrolled cell proliferation disease
- neurodegenerationProgressive loss of neurons
- ParkinsonSurname behind tremors
- ataxiaImpaired voluntary movement control
inhibitor · oncogene · tumor suppressor · mutation · dysfunction · drug discovery · biomarker
domain
Area of control
- coiled-coilHelices twisted together
- crystal structureOrdered atomic arrangement in solids
- binding siteMolecular attachment region