HDAC
Histone tail enzyme
HDAC stands for histone deacetylase, an enzyme that removes acetyl groups from proteins called histones.
This action tightens DNA around histones, making genes less accessible and typically reducing their expression.
HDAC inhibitors are drugs used in cancer treatment and psychiatric research: The patient responded well to HDAC inhibitor therapy.
Chromosome-packing protein
- nucleosomeHistone-DNA complex
- acetylationAcetyl group attachment
- methylationAttaching a methyl group
- remodelingAltering existing structures
transcription · compaction · accessibility · reader · writer · eraser · condensation · regulatory
Acetyl-removing chromatin enzyme
- acetylationAcetyl group attachment
- lysineEssential amino acid
- chromatinNuclear protein-wrapped genetic material
- epigeneticAffecting gene expression, not sequence
catalytic · substrate · active site · enzymatic · hydrolase · acetyl group · nucleosome · catalysis
Gene preventing uncontrolled growth
- oncologyCancer medicine specialty
- leukemiaMalignancy of blood-forming tissues
- lymphomaCancer from immune cells
- myelomaMalignant plasma cell neoplasm
differentiation · angiogenesis · metastasis · biomarker · prognosis · malignancy · hematological · carcinoma
Programmed cell death
- anticancerOpposing malignant cell growth
- clinical trialHuman subject research experiment
- chemotherapyAnti-cancer drug treatment
- combination therapyUsing multiple treatments together
drug resistance · cytotoxicity · selectivity · therapeutic · pharmacology · dose-response · treatment
Incapacitating final blow
- knockdownBlow causing a fall
- assayCompositional evaluation procedure
- inhibitionMental check on behavior
- overexpressionExcessive gene activity
cell line · CRISPR · mechanism · pathway · signaling · publication · laboratory · experiment
histone
Chromosome-packing protein
- nucleosomeHistone-DNA complex
- acetylationAcetyl group attachment
- methylationAttaching a methyl group
remodeling · transcription · compaction · accessibility · reader · writer · eraser · condensation · regulatory
histone deacetylase
Acetyl-removing chromatin enzyme
- acetylationAcetyl group attachment
- lysineEssential amino acid
- chromatinNuclear protein-wrapped genetic material
epigenetic · catalytic · substrate · active site · enzymatic · hydrolase · acetyl group · nucleosome · catalysis
tumor suppressor
Gene preventing uncontrolled growth
- oncologyCancer medicine specialty
- leukemiaMalignancy of blood-forming tissues
- lymphomaCancer from immune cells
myeloma · differentiation · angiogenesis · metastasis · biomarker · prognosis · malignancy · hematological · carcinoma · relapsed
apoptosis
Programmed cell death
- anticancerOpposing malignant cell growth
- clinical trialHuman subject research experiment
- chemotherapyAnti-cancer drug treatment
combination therapy · drug resistance · cytotoxicity · selectivity · therapeutic · pharmacology · dose-response · treatment
knockout
Incapacitating final blow
- knockdownBlow causing a fall
- assayCompositional evaluation procedure
- inhibitionMental check on behavior
overexpression · cell line · CRISPR · mechanism · pathway · signaling · publication · laboratory · experiment · screening
- Epigeneticsepigenetics, histone, nucleosome, methylation, acetylation
- Chromatin Proteinshistones, chromatin, nucleosome, readers, writers
- CoregulatorsTRAP, HAT
- Deacetylaseshistone deacetylase
- enzymeslipase, amylase, protease, kinase, enzyme
- Zinc EnzymesACE, collagenase, histone deacetylase