E3 ligase
Protein degradation tagger
E3 ligase is an enzyme that tags proteins for destruction by attaching ubiquitin molecules to them.
The tagged proteins are then recognized and degraded by the cell's proteasome.
E3 ligases determine which specific proteins get marked, making them crucial regulators of cellular processes from the cell cycle to immune response: Researchers are developing drugs that hijack E3 ligases to degrade disease-causing proteins.
- degradationDecline in condition
- substrateUnderlying supporting material
- taggingAttaching identifying markers
- destructionAct of completely ruining
- cascadeSuccessive downward flow
conjugation · lysine · chain · marking · turnover · adaptor · recognition · hypoxia · cancer · protein · complex
- Ligases
- SUMOylation