histone deacetylase
Gene silencing enzyme
Histone deacetylase is an enzyme that removes acetyl groups from histone proteins, causing DNA to wind more tightly around histones and thereby suppressing gene expression.
Often abbreviated HDAC.
These enzymes play crucial roles in regulating which genes are active in a cell.
HDAC inhibitors are used in cancer treatment to reactivate tumor-suppressing genes: The drug targets histone deacetylase to restore normal cell function.
Acetyl group attachment
- lysineEssential amino acid
- substrateUnderlying supporting material
- active siteEnzyme region binding substrates
- catalysisAccelerating reactions without consumption
Histone-DNA complex
- centromereChromosome's spindle attachment site
- telomereProtective chromosome terminus
Uncontrolled cell proliferation disease
- leukemiaMalignancy of blood-forming tissues
- lymphomaCancer from immune cells
- neurodegenerationProgressive loss of neurons
- Huntington'sInherited neurodegenerative condition
Alzheimer's · inflammatory disease · metabolic disorder · autoimmunity · muscular dystrophy · tumor suppressor
Managing when DNA activates
- imprintingRapid early learning attachment
- transgenerationalCrossing age cohorts
- reprogrammingAltering original functional instructions
- stem cellUnspecialized, self-renewing biological unit
Treatment for malignant disease
- clinical trialHuman subject research experiment
- anticancerOpposing malignant cell growth
- neuroprotectionSafeguarding neurons from damage
- combination therapyUsing multiple treatments together
acetylation
Acetyl group attachment
- lysineEssential amino acid
- substrateUnderlying supporting material
- active siteEnzyme region binding substrates
catalysis · hydrolase · cofactor · inhibition
nucleosome
Histone-DNA complex
- centromereChromosome's spindle attachment site
- telomereProtective chromosome terminus
cancer
Uncontrolled cell proliferation disease
- leukemiaMalignancy of blood-forming tissues
- lymphomaCancer from immune cells
- neurodegenerationProgressive loss of neurons
Huntington's · Alzheimer's · inflammatory disease · metabolic disorder · autoimmunity · muscular dystrophy · tumor suppressor
gene regulation
Managing when DNA activates
- imprintingRapid early learning attachment
- transgenerationalCrossing age cohorts
- reprogrammingAltering original functional instructions
cancer therapy
Treatment for malignant disease
- clinical trialHuman subject research experiment
- anticancerOpposing malignant cell growth
- neuroprotectionSafeguarding neurons from damage
- Epigeneticsepigenetics, nucleosome, methylation, acetylation, chromatin
- Chromatin Proteinshistones, chromatin, nucleosome, readers, writers
- DeacetylasesHDAC
- DNA Proteinshistones, repressor, repressors, activator, activators
- Zinc EnzymesACE, collagenase, HDAC
- enzymeslipase, amylase, protease, kinase, enzyme