cell line
Lab-grown cellular dynasty
A cell line is a population of cells grown in a laboratory that can replicate indefinitely, derived from a single original cell or tissue sample.
Cell lines are fundamental tools in biological research, drug testing, and vaccine production.
The most famous is HeLa, derived from cervical cancer cells taken from Henrietta Lacks in 1951, which has been used in countless medical studies.
The lab maintains several cell lines for testing new compounds.
Immortal human cell line
- telomeraseChromosome-tip lengthening enzyme
- transformationThorough change in form
- senescenceGradual functional decline with age
- continuousWithout pause or gap
established · oncogene · immortalization · finite · primary · karyotype · genetic drift · clonal
Segment of text
- subcultureGroup with alternative norms
- mediaInformation distribution channels
- serumBlood's watery portion
- flaskPortable liquid container
incubator · plating · cryopreservation · thawing · monolayer · suspension · mycoplasma · contamination
Test for prohibited substances
- transfectionNon-viral gene introduction
- knockoutIncapacitating final blow
- knockdownBlow causing a fall
- CRISPRGene-editing molecular machinery
gene expression · reporter · phenotype · genotype · biomarker · toxicology · pharmacology · oncology
Vessel for growing organisms
- biopharmaceuticalBiotechnology-derived medicinal product
- monoclonal antibodyEngineered protein from cloned cells
- scale-upProportional increase in magnitude
- yieldProduce or relinquish
harvest · downstream · upstream · perfusion · therapeutic · manufacturing · GMP · titer
HeLa
Immortal human cell line
- telomeraseChromosome-tip lengthening enzyme
- transformationThorough change in form
- senescenceGradual functional decline with age
continuous · established · oncogene · immortalization · finite · primary · karyotype · genetic drift · clonal · neoplastic
passage
Segment of text
- subcultureGroup with alternative norms
- mediaInformation distribution channels
- serumBlood's watery portion
flask · incubator · plating · cryopreservation · thawing · monolayer · suspension · mycoplasma · contamination · sterility
drug screening
Test for prohibited substances
- transfectionNon-viral gene introduction
- knockoutIncapacitating final blow
- knockdownBlow causing a fall
CRISPR · gene expression · reporter · phenotype · genotype · biomarker · toxicology · pharmacology · oncology · assay
bioreactor
Vessel for growing organisms
- biopharmaceuticalBiotechnology-derived medicinal product
- monoclonal antibodyEngineered protein from cloned cells
- scale-upProportional increase in magnitude
yield · harvest · downstream · upstream · perfusion · therapeutic · manufacturing · GMP · titer · productivity
- Biology Labpetri dish, microscope, pipette, test tube, beaker
- cell biologycytoplasm, ribosome, mitochondria, nucleus, organelles
- biological materialstissue, blood, plasma, serum, bone marrow
- lab biologypetri dish, test tube, pipette, PCR, tissue culture
- cell culturetissue culture, culture plate, culture dish, subculture, plating
- tumor modelsxenograft
cell linewhole organism
animal model · tissue · organ · organoid · clinical trial