S-adenosylmethionine

Universal methyl donor

S-adenosylmethionine is a compound naturally produced in the body from the amino acid methionine and ATP.

It serves as a methyl donor in countless biochemical reactions, including the synthesis of neurotransmitters, proteins, and DNA.

Often abbreviated SAM or SAMe, it's sold as a dietary supplement marketed for depression, joint pain, and liver health: My doctor suggested trying SAMe for my mood.

biochemistry

methionine

Sulfur-bearing essential amino-acid

sulfur · enzyme · biosynthesis · metabolism · catalysis · substrate · coenzyme · cellular · amino acid · epigenetics

supplement

joint health

Condition of body connections

nutraceutical · capsule · tablet · dosage · bioavailability · oral · over-the-counter · natural remedy · holistic · alternative medicine

clinical

antidepressant

Drug treating persistent despair

efficacy · tolerability · psychiatric · rheumatology · gastroenterology · symptom relief · placebo-controlled · double-blind · side effects · drug interaction

Categories
Opposites
methyl group transfer direction

S-adenosylmethioninehomocysteine

Methionine breakdown product

methionine · adenosine

epigenetic effect

S-adenosylmethioninealpha-ketoglutarate

Tricarboxylic acid cycle metabolite

vitamin C

Family

adenosine, adenine, methyl, methylation, methylated

Familiarity
Top 2,000,000
Profile
Used worldwide · Timeless · Concrete · Rated G