nitrogen mustard
Vesicant cancer drug
Nitrogen mustard refers to a class of chemical compounds related to mustard gas, developed as chemical warfare agents but now used primarily in cancer chemotherapy.
These cytotoxic drugs work by damaging DNA and preventing cell division: The oncologist prescribed nitrogen mustard for the lymphoma.
The term encompasses several drugs including mechlorethamine, the first chemotherapy agent used to treat cancer.
Cancer from immune cells
- leukemiaMalignancy of blood-forming tissues
- myelomaMalignant plasma cell neoplasm
- cytotoxicToxic to cells
- DNA crosslinkingCovalent joining of genetic strands
cell cycle · intravenous · oncology · remission · combination therapy · infusion · protocol
Causes cancer
- mutagenicCausing permanent DNA changes
- teratogenicCausing fetal malformations
- cytotoxicToxic to cells
- hazardousLikely to cause injury
poisonous · DNA damage · mutagenesis · carcinogenesis · immunosuppression · alopecia · nausea · vomiting
Toxic agent for warfare
- World War IFirst global military conflict
- YpresFlemish city, wartime ruins
- weaponizationMaking something harmful
- stockpileAccumulated reserve supply
demilitarization · military history · trench warfare · gas mask · protective gear · banned substance · war crime
Extremely intense or severe
- skin lesionsDamaged areas of dermis
- vesiclesSmall enclosed sacs
- bullaeLarge fluid-filled skin lesions
- erythemaCutaneous vascular flushing
necrosis · conjunctivitis · chemical burn · decontamination · ulceration · eschar · wound care
lymphoma
Cancer from immune cells
- leukemiaMalignancy of blood-forming tissues
- myelomaMalignant plasma cell neoplasm
- cytotoxicToxic to cells
DNA crosslinking · cell cycle · intravenous · oncology · remission · combination therapy · infusion · protocol
carcinogenic
Causes cancer
- mutagenicCausing permanent DNA changes
- teratogenicCausing fetal malformations
- cytotoxicToxic to cells
hazardous · poisonous · DNA damage · mutagenesis · carcinogenesis · immunosuppression · alopecia · nausea · vomiting · leukopenia
chemical weapon
Toxic agent for warfare
- World War IFirst global military conflict
- YpresFlemish city, wartime ruins
- weaponizationMaking something harmful
stockpile · demilitarization · military history · trench warfare · gas mask · protective gear · banned substance · war crime
blistering
Extremely intense or severe
- skin lesionsDamaged areas of dermis
- vesiclesSmall enclosed sacs
- bullaeLarge fluid-filled skin lesions
erythema · necrosis · conjunctivitis · chemical burn · decontamination · ulceration · eschar · wound care
- carcinogensasbestos, benzene, formaldehyde, arsenic, tobacco smoke
- alkylators
- Cytotoxinsmethotrexate, 5-fluorouracil, taxol, antimetabolites, ricin
- vesicants
nitrogen mustardtargeted therapy
Treatment hitting specific molecules
immunotherapy · monoclonal antibody · precision medicine · personalized medicine · gene therapy
mustard, nitrogen, mustards, nitrate, nitrite, nitrates, nitric, mustard gas, mustardy