hemophilias
Hereditary bleeding conditions
Hemophilias is the plural of hemophilia, a group of genetic disorders in which blood fails to clot properly.
The most common forms result from deficiencies in specific clotting factors, causing prolonged bleeding from injuries and spontaneous internal bleeding.
The royal hemophilias of European dynasties traced back to Queen Victoria.
Coagulation protein enabling clotting
- clottingBlood solidifying process
- fibrinClot-forming protein
- thrombinSerine protease enabling coagulation
- plateletsCell fragments enabling coagulation
prothrombin · hemostasis · plasma · fibrinogen · clotting factors · inhibitors · half-life
Profuse discharge of blood
- bruisingCausing tissue discoloration
- clottingBlood solidifying process
- transfusionTransfer of blood intravenously
- hematomaBlood collected outside vessels
petechiae · wounds · hemostasis · internal bleeding · nosebleeds · infusion · prophylaxis · bleeders
Masked unless paired identically
- carrierOne that transports
- chromosomesGene-bearing nuclear structures
- mutationPermanent DNA alteration
- pedigreeRecord of descent
gene · family history · genetic counseling · genetic testing · prenatal testing · sex-linked · maternal inheritance · germline
Steeping to extract essence
- prophylaxisPreventive medical treatment
- gene therapyMedical DNA modification treatment
Hereditary hemoglobin production defect
- sickle cellInherited blood cell malformation
- anemiaRed cell deficiency
- bleeding disordersImpaired blood clotting conditions
- congenitalExisting from birth
factor VIII
Coagulation protein enabling clotting
- clottingBlood solidifying process
- fibrinClot-forming protein
- thrombinSerine protease enabling coagulation
platelets · prothrombin · hemostasis · plasma · fibrinogen · clotting factors · inhibitors · half-life
hemorrhage
Profuse discharge of blood
- bruisingCausing tissue discoloration
- clottingBlood solidifying process
- transfusionTransfer of blood intravenously
hematoma · petechiae · wounds · hemostasis · internal bleeding · nosebleeds · infusion · prophylaxis · bleeders · gauze
recessive
Masked unless paired identically
- carrierOne that transports
- chromosomesGene-bearing nuclear structures
- mutationPermanent DNA alteration
pedigree · gene · family history · genetic counseling · genetic testing · prenatal testing · sex-linked · maternal inheritance · germline · DNA
infusion
Steeping to extract essence
- prophylaxisPreventive medical treatment
- gene therapyMedical DNA modification treatment
thalassemia
Hereditary hemoglobin production defect
- sickle cellInherited blood cell malformation
- anemiaRed cell deficiency
- bleeding disordersImpaired blood clotting conditions