HER2
Cancer growth receptor
HER2 is a protein that promotes cell growth, found on the surface of some cells.
In medicine, HER2 refers specifically to a gene that, when overexpressed, drives aggressive breast and stomach cancers.
HER2-positive cancers grow faster but respond to targeted therapies: She tested HER2-positive, so her oncologist recommended Herceptin.
Increase in intensity
- overexpressionExcessive gene activity
- mutationPermanent DNA alteration
- tyrosine kinasePhosphotransferase for proteins
- signalingConveying information nonverbally
pathway · proliferation · receptor · phosphorylation · gene · transcription · cellular · transformation
Excessive gene activity
- amplificationIncrease in intensity
- FISHChromosome sequence visualization method
- testingExamining to evaluate
- diagnosisIdentification of illness
prognosis · biopsy · scoring · equivocal · pathology · detection · screening · histopathology
Engineered protein from cloned cells
- ADCMilitary personal assistant
- immunotherapyDisease treatment via body's defenses
- humanizedMade more human-like
- adjuvantImmunity-boosting additive
Breast tissue X-ray
- ductalOf or relating to ducts
- invasiveEncroaching without welcome
- mastectomySurgical breast removal
- BRCA1Tumor suppressor gene
hormone receptor · lumpectomy · reconstruction · metastatic · lymph node · inflammatory · lobular · oncologist
Of stomach and esophagus
- stomachDigestive organ below chest
- adenocarcinomaGlandular tissue malignancy
- esophagealOf the swallowing passage
- advancedFar along in development
amplification
Increase in intensity
- overexpressionExcessive gene activity
- mutationPermanent DNA alteration
- tyrosine kinasePhosphotransferase for proteins
signaling · pathway · proliferation · receptor · phosphorylation · gene · transcription · cellular · transformation · carcinogenesis
overexpression
Excessive gene activity
- amplificationIncrease in intensity
- FISHChromosome sequence visualization method
- testingExamining to evaluate
diagnosis · prognosis · biopsy · scoring · equivocal · pathology · detection · screening · histopathology · laboratory
monoclonal antibody
Engineered protein from cloned cells
- ADCMilitary personal assistant
- immunotherapyDisease treatment via body's defenses
- humanizedMade more human-like
adjuvant · drug resistance · precision medicine · clinical trial
mammogram
Breast tissue X-ray
- ductalOf or relating to ducts
- invasiveEncroaching without welcome
- mastectomySurgical breast removal
BRCA1 · hormone receptor · lumpectomy · reconstruction · metastatic · lymph node · inflammatory · lobular · oncologist · survivor
gastroesophageal
Of stomach and esophagus
- stomachDigestive organ below chest
- adenocarcinomaGlandular tissue malignancy
- esophagealOf the swallowing passage
advanced · metastatic · upper GI · endoscopy
- breast cancerbreast cancer, mastectomy, mammogram, lumpectomy, mammography
- oncologycancer, tumor, carcinoma, metastasis, malignancy
- breast healthbreast cancer, breast exam, breast health, breast lumps, breast pain
- biomarkersbiomarkers, troponin, PSA, creatinine, hemoglobin A1c
- Cancer BiomarkersBRCA1, PSA, BCR-ABL, telomerase
- Drug Targetsreceptor, enzyme, kinase, transporter, protease
- let her ripProceed without restraint
- under her breath
- Her HighnessRoyal feminine honorific
- let nature take her courseAllow things to proceed unaided
- asking for her hand
- lost her sheep