tyrosine kinase
Protein-modifying catalyst
Tyrosine kinase is an enzyme that transfers phosphate groups to tyrosine residues on proteins, activating or deactivating them.
This mechanism is fundamental to cell signaling—controlling growth, division, and differentiation.
Mutations in tyrosine kinases are implicated in many cancers, making them targets for drugs like imatinib: tyrosine kinase inhibitors have transformed cancer treatment.
- phosphorylationPhosphate group attachment process
- receptorSignal-receiving molecule
- enzymeProtein that hastens reactions
- signalingConveying information nonverbally
- ATPCell's energy molecule
protein · inhibitor · cancer · mutation · kinase · substrate · growth factor · cell growth · insulin · cascade · oncogene · cell division · membrane · activation · magic bullet · leukemia · therapeutic · targeted therapy
- Phosphorylationphosphate group, kinase, phosphatase, ATP, ADP
- cell signalingreceptor, ligand, receptors, signaling, kinase
- Drug Targetsreceptor, enzyme, kinase, transporter, protease
- enzymeslipase, amylase, protease, kinase, enzyme
- Transferasesglycosyltransferases, transaminase, kinase
- leukemialeukemia, acute leukemia, leukaemia, AML, ALL