BCR-ABL
Philadelphia chromosome product
BCR-ABL is an abnormal fusion gene formed when parts of two chromosomes swap places, joining the BCR gene to the ABL gene.
This chromosomal rearrangement, called the Philadelphia chromosome, produces a protein that drives uncontrolled cell division.
BCR-ABL is the hallmark of chronic myeloid leukemia and some acute leukemias: The patient tested positive for BCR-ABL.
Testing for BCR-ABL guides diagnosis and monitors treatment response to targeted therapies like imatinib.
Movement to another place
- tyrosine kinasePhosphotransferase for proteins
- oncogeneTumor-inducing genetic element
- breakpointCode execution pause marker
- exonProtein-coding gene segment
The complete amount
- myeloproliferativeOveractive bone marrow condition
- white blood cellsPathogen-fighting components of plasma
- bone marrowBlood cell birthplace
- leukocytosisExcess circulating white cells
stem cell · clonal expansion · disease progression · relapse · remission · prognosis · survival rate
Treatment hitting specific molecules
- second-generationDescendants of original arrivals
- combination therapyUsing multiple treatments together
- stem cell transplantInfusion of blood-forming precursors
- clinical trialHuman subject research experiment
DNA amplification technique
- FISHChromosome sequence visualization method
- cytogeneticsChromosome structure and inheritance science
- karyotypeOrganized chromosome display
- bone marrow biopsyTissue sample from skeleton's interior
translocation
Movement to another place
- tyrosine kinasePhosphotransferase for proteins
- oncogeneTumor-inducing genetic element
- breakpointCode execution pause marker
exon · transcript · mRNA
ALL
The complete amount
- myeloproliferativeOveractive bone marrow condition
- white blood cellsPathogen-fighting components of plasma
- bone marrowBlood cell birthplace
leukocytosis · stem cell · clonal expansion · disease progression · relapse · remission · prognosis · survival rate
targeted therapy
Treatment hitting specific molecules
- second-generationDescendants of original arrivals
- combination therapyUsing multiple treatments together
- stem cell transplantInfusion of blood-forming precursors
PCR
DNA amplification technique
- FISHChromosome sequence visualization method
- cytogeneticsChromosome structure and inheritance science
- karyotypeOrganized chromosome display
- oncologycancer, tumor, carcinoma, metastasis, malignancy
- Tyrosine KinasesLyn, Met, Ron, DDR2
- Cancer BiomarkersBRCA1, HER2, PSA, telomerase
- Leukemia Markersmyeloperoxidase
- leukemialeukemia, acute leukemia, leukaemia, AML, ALL
- MPNsPV, ET