hyperinflammation
Body attacks itself
Hyperinflammation is an excessive or uncontrolled inflammatory response by the immune system, often causing more damage than the original threat.
The term gained prominence during COVID-19, where hyperinflammation could lead to organ failure and death.
Also called a cytokine storm when referring to the flood of immune signaling proteins involved: The patient's hyperinflammation required immunosuppressive treatment.
Excessive immune signaling crisis
- immune responseBody fighting foreign threats
- interleukinsImmune cell signaling proteins
- T-cellsThymus-matured immune lymphocytes
- neutrophilsPathogen-engulfing white blood cells
autoimmunity · leukocytes · innate immunity · immunopathology · hyperimmune · antibodies · lymphocytes · histamine
Dangerous inflammatory infection response
- COVID-19WHO-named 2019 coronavirus
- feverElevated body temperature
- shockViolent sudden disturbance
- vasculitisVessel wall inflammation
critical illness · ICU · organ damage · hypoxia · mortality
Drugs reducing body defenses
- corticosteroidsInflammation-suppressing steroid medications
- dexamethasoneSynthetic corticosteroid reducing inflammation
- biologicsDrugs derived from organisms
- immunomodulatorsAgents modifying bodily defenses
colchicine · NSAIDs · monoclonal antibodies · clinical trials · remission · supportive care · antivirals · combination therapy
Harm to body cells
- cell deathCessation of cellular life
- necrosisLocalized cell death
- apoptosisProgrammed cell death
- edemaPathological tissue puffiness
cytokine storm
Excessive immune signaling crisis
- immune responseBody fighting foreign threats
- interleukinsImmune cell signaling proteins
- T-cellsThymus-matured immune lymphocytes
neutrophils · autoimmunity · leukocytes · innate immunity · immunopathology · hyperimmune · antibodies · lymphocytes · histamine · prostaglandins
sepsis
Dangerous inflammatory infection response
vasculitis · critical illness · ICU · organ damage · hypoxia · mortality
immunosuppressants
Drugs reducing body defenses
- corticosteroidsInflammation-suppressing steroid medications
- dexamethasoneSynthetic corticosteroid reducing inflammation
- biologicsDrugs derived from organisms
immunomodulators · colchicine · NSAIDs · monoclonal antibodies · clinical trials · remission · supportive care · antivirals · combination therapy
tissue damage
Harm to body cells
- cell deathCessation of cellular life
- necrosisLocalized cell death
- apoptosisProgrammed cell death
edema · fibrosis · thrombosis · pathogenesis
hyperinflammationtissue regeneration
Biological self-repair of damage
tissue repair · resolution · wound healing · recovery · restoration
hyper, inflame, inflamed, inflaming, inflammation, inflammatory, flame, flames, flamed