pharmacokinetics
Medicine body journey
Pharmacokinetics is the study of how drugs move through the body—how they're absorbed, distributed, metabolized, and eliminated.
The field examines what the body does to a drug, as opposed to pharmacodynamics, which studies what the drug does to the body.
The pharmacokinetics of the new medication suggested twice-daily dosing.
Divided into separate sections
- AUCIntegrated area beneath plotted line
- half-lifePeriod for fifty-percent reduction
- clearancePermitted passage or approval
- steady-stateCondition of constant balance
trough · peak · superposition · Bayesian · covariate · variability
Act of removing entirely
Metabolic chemical conversion
- hepaticRelating to liver
- CYP3A4Hepatic drug-processing enzyme
- CYP2D6Drug-metabolizing liver enzyme
- oxidationLosing electrons chemically
reduction · hydrolysis · conjugation · metabolites · clearance · polymorphism · phenotyping
Fraction reaching active circulation
- permeabilityAbility to transmit fluids
- oralOf the mouth
- sublingualUnder the tongue
- transdermalPassing through skin
intravenous · intramuscular · subcutaneous · gastrointestinal · mucosal · epithelial · membrane · solubility
Blood and egg protein
- compartmentalDivided into separate sections
- peripheralExternal computer add-on
- centralIn the middle, primary
- steady-stateCondition of constant balance
accumulation · redistribution · intracellular · extracellular · interstitial · lymphatic · adipose
compartmental
Divided into separate sections
- AUCIntegrated area beneath plotted line
- half-lifePeriod for fifty-percent reduction
- clearancePermitted passage or approval
steady-state · trough · peak · superposition · Bayesian · covariate · variability
elimination
Act of removing entirely
biotransformation
Metabolic chemical conversion
oxidation · reduction · hydrolysis · conjugation · metabolites · clearance · polymorphism · phenotyping
bioavailability
Fraction reaching active circulation
- permeabilityAbility to transmit fluids
- oralOf the mouth
- sublingualUnder the tongue
transdermal · intravenous · intramuscular · subcutaneous · gastrointestinal · mucosal · epithelial · membrane · solubility · AUC
albumin
Blood and egg protein
- compartmentalDivided into separate sections
- peripheralExternal computer add-on
- centralIn the middle, primary
steady-state · accumulation · redistribution · intracellular · extracellular · interstitial · lymphatic · adipose
pediatric
Relating to child medicine