substance P
Nociceptive neural signal
Substance P is a neuropeptide that transmits pain signals and triggers inflammation.
It plays a role in the body's response to injury and stress, signaling between nerve cells in the brain, spinal cord, and gut.
The P stands for "powder," referring to how it was first isolated.
Blocking substance P receptors may reduce chronic pain.
Protective tissue response
- neurogenicCaused by neural activity
- capsaicinChili heat compound
- analgesicPain-relieving medication
- migraineSevere neurological head pain
headache · arthritis · fibromyalgia · chronic pain · acute pain · sensitization · visceral pain · antagonist
Nerve signal crossing point
- neuronImpulse-conducting cell
- axonNeuron's signal-sending projection
- dendriteNeuron's input branch
- spinal cordBrain's extension through vertebrae
ganglion · vesicle · exocytosis · depolarization · action potential · afferent · unmyelinated · peripheral nerve
Short amino acid chain
- neurotransmitterSynaptic chemical messenger
- neuropeptideNeuronal protein-like signaling molecule
- amino acidsOrganic compounds forming proteins
- polypeptideAmino acid polymer
bioactive · ligand · precursor · synthesis · degradation · secretion · release · expression
Relaxation of vessel walls
- bronchoconstrictionAirway narrowing from muscle contraction
- smooth muscleInvoluntary contractile tissue
- salivationMouth producing digestive fluid
- vomitingExpelling stomach contents orally
emesis · antiemetic · edema · mast cell · histamine · immune response · pruritus · itching
inflammation
Protective tissue response
- neurogenicCaused by neural activity
- capsaicinChili heat compound
- analgesicPain-relieving medication
migraine · headache · arthritis · fibromyalgia · chronic pain · acute pain · sensitization · visceral pain · antagonist · pain relief
synapse
Nerve signal crossing point
spinal cord · ganglion · vesicle · exocytosis · depolarization · action potential · afferent · unmyelinated · peripheral nerve · central nervous system
peptide
Short amino acid chain
- neurotransmitterSynaptic chemical messenger
- neuropeptideNeuronal protein-like signaling molecule
- amino acidsOrganic compounds forming proteins
polypeptide · bioactive · ligand · precursor · synthesis · degradation · secretion · release · expression · endogenous
vasodilation
Relaxation of vessel walls
- bronchoconstrictionAirway narrowing from muscle contraction
- smooth muscleInvoluntary contractile tissue
- salivationMouth producing digestive fluid
vomiting · emesis · antiemetic · edema · mast cell · histamine · immune response · pruritus · itching · wound healing
- chemical compoundsacetone, aldehydes, amines, esters, ketones
- neuroscienceneuron, MRI, brain, neurons, synapses
- irritantstear gas, pepper spray, CS gas, mace, bear spray
- Neurochemistrydopamine, serotonin, norepinephrine, epinephrine, acetylcholine
- Neuroactive Compoundsacetylcholine, dopamine, GABA, glutamate, glycine
- Neurochemicalsacetylcholine, dopamine, serotonin, norepinephrine, epinephrine
substance Pendorphins
Body's innate pain blockers
morphine · analgesics · GABA · endocannabinoids · serotonin
- substance abuseHarmful habitual intoxicant use
- controlled substanceLegally regulated intoxicant or medication
- banned substancesMaterials forbidden by law
- toxic substancesMaterials harmful to life
- volatile substancesEasily evaporating chemical materials
- illegal substancesForbidden drugs or materials