clozapine
Treatment-resistant psychiatric drug
Clozapine is an antipsychotic medication used primarily to treat schizophrenia that hasn't responded to other drugs.
It's considered uniquely effective for treatment-resistant cases but requires regular blood monitoring because it can cause a dangerous drop in white blood cells.
She was finally stabilized on clozapine after years of failed treatments.
Perceptions without external cause
- delusionsFirmly held false beliefs
- psychosisSevere reality detachment
- paranoiaIrrational persecution fears
- negative symptomsLost or reduced mental capacities
flat affect · anhedonia · social withdrawal · cognitive deficits · auditory hallucinations · thought disorder · catatonia · schizoaffective
Insufficient neutrophils in blood
- seizuresInvoluntary convulsions or takings
- hypersalivationExcessive oral secretion
- droolingSaliva spilling from mouth
- weight gainBody mass accumulation
metabolic syndrome · myocarditis · tachycardia · constipation · sedation · hypotension · hyperglycemia · QT prolongation
Dopamine-blocking psychiatric medication
- chlorpromazinePhenothiazine antipsychotic drug
- atypicalNot conforming to type
- dopamineReward-linked neural messenger
- serotoninMood-regulating brain chemical
receptor · antagonist · neuroleptic · psychotropic · second-generation
Resistant to heat/control
- efficacyAbility to produce results
- responseAnswer to stimulus
- remissionTemporary disease absence
- relapse preventionStrategies against returning symptoms
suicidality · aggression · polypharmacy · augmentation · monotherapy · maintenance · discontinuation
Diagnostic fluid analysis
- white blood cellImmune system's cellular soldier
- registryOfficial record of entries
- titrationMeasuring concentration by addition
- baselineStandard for comparison
weekly · biweekly · monthly · dispensing · compliance · laboratory
Fraction reaching active circulation
- pharmacokineticsDrug fate in body
- half-lifePeriod for fifty-percent reduction
- metabolismCellular nutrient conversion
- dosageMeasured medicine amount
titration · oral · tablet · formulation · absorption · distribution · cytochrome · drug interaction
hallucinations
Perceptions without external cause
- delusionsFirmly held false beliefs
- psychosisSevere reality detachment
- paranoiaIrrational persecution fears
negative symptoms · flat affect · anhedonia · social withdrawal · cognitive deficits · auditory hallucinations · thought disorder · catatonia · schizoaffective · refractory
neutropenia
Insufficient neutrophils in blood
- seizuresInvoluntary convulsions or takings
- hypersalivationExcessive oral secretion
- droolingSaliva spilling from mouth
weight gain · metabolic syndrome · myocarditis · tachycardia · constipation · sedation · hypotension · hyperglycemia · QT prolongation · leukopenia
haloperidol
Dopamine-blocking psychiatric medication
- chlorpromazinePhenothiazine antipsychotic drug
- atypicalNot conforming to type
- dopamineReward-linked neural messenger
serotonin · receptor · antagonist · neuroleptic · psychotropic · second-generation
refractory
Resistant to heat/control
relapse prevention · suicidality · aggression · polypharmacy · augmentation · monotherapy · maintenance · discontinuation
blood test
Diagnostic fluid analysis
- white blood cellImmune system's cellular soldier
- registryOfficial record of entries
- titrationMeasuring concentration by addition
baseline · weekly · biweekly · monthly · dispensing · compliance · laboratory
bioavailability
Fraction reaching active circulation
- pharmacokineticsDrug fate in body
- half-lifePeriod for fifty-percent reduction
- metabolismCellular nutrient conversion
dosage · titration · oral · tablet · formulation · absorption · distribution · cytochrome · drug interaction · smoking
clozapinecognitive behavioral therapy
Treatment restructuring harmful thought patterns
psychotherapy · talk therapy · electroconvulsive therapy · behavioral therapy