chlorpromazine
First major tranquilizer
Chlorpromazine is an antipsychotic medication, the first of its class, introduced in the 1950s.
It treats schizophrenia, severe anxiety, and nausea by blocking dopamine receptors in the brain.
Its development revolutionized psychiatric treatment, shifting care from institutionalization toward medication management.
Brand name: Thorazine.
Psychiatric medication blocking dopamine
- dopamine antagonistBlocks neurotransmitter binding sites
- psychotropicAltering mental activity
- haloperidolDopamine-blocking psychiatric medication
- first-generationEarliest iteration of something
Severe reality detachment
- hallucinationsPerceptions without external cause
- delusionsFirmly held false beliefs
- thought disorderDisrupted patterns of reasoning
- negative symptomsLost or reduced mental capacities
Prevents nausea and vomiting
- nauseaPre-vomiting stomach discomfort
- vomitingExpelling stomach contents orally
- preanestheticBefore surgical numbness
- maniaIntense, consuming obsession
bipolar disorder · anxiety · tetanus · porphyria · hospice care
Movement disorder causing postures
- parkinsonismMotor syndrome with tremor, rigidity
- anticholinergicBlocks acetylcholine receptors
- dry mouthInsufficient saliva production
- photosensitivityReactivity to radiant energy
State of near-sleep
- somnolenceAbnormal urge to doze
- lethargyAbnormal drowsiness and apathy
- calmingInducing a settled state
- tranquilizationInducing artificial calm
Decade after WWII
- deinstitutionalizationReleasing long-term patients systemwide
- asylumShelter from persecution
- state hospitalGovernment-run psychiatric facility
- psychopharmacologyStudy of drug-brain interactions
neuroleptic
Psychiatric medication blocking dopamine
- dopamine antagonistBlocks neurotransmitter binding sites
- psychotropicAltering mental activity
- haloperidolDopamine-blocking psychiatric medication
psychosis
Severe reality detachment
- hallucinationsPerceptions without external cause
- delusionsFirmly held false beliefs
- thought disorderDisrupted patterns of reasoning
negative symptoms · catatonia · paranoia · relapse prevention
antiemetic
Prevents nausea and vomiting
- nauseaPre-vomiting stomach discomfort
- vomitingExpelling stomach contents orally
- preanestheticBefore surgical numbness
mania · bipolar disorder · anxiety · tetanus · porphyria · hospice care
dystonia
Movement disorder causing postures
- parkinsonismMotor syndrome with tremor, rigidity
- anticholinergicBlocks acetylcholine receptors
- dry mouthInsufficient saliva production
drowsiness
State of near-sleep
- somnolenceAbnormal urge to doze
- lethargyAbnormal drowsiness and apathy
- calmingInducing a settled state
tranquilization · chemical restraint · stupor · obtundation · oversedation
1950s
Decade after WWII
- deinstitutionalizationReleasing long-term patients systemwide
- asylumShelter from persecution
- state hospitalGovernment-run psychiatric facility
chlorpromazineamphetamine
Central nervous system stimulant
methamphetamine · stimulant · levodopa · dextroamphetamine · cocaine
chlorpromazineantidepressant
Drug treating persistent despair
bupropion · stimulant medication · fluoxetine · sertraline · amitriptyline
chlorine, chloroform, propylene, chlorinated, chlorella, chloral