amyloid
Misfolded protein deposit
Amyloid refers to proteins that misfold and clump together in abnormal, insoluble deposits.
These fibrous aggregates accumulate in tissues and organs, interfering with normal function.
Amyloid plaques in the brain are a hallmark of Alzheimer's disease: The scan revealed significant amyloid buildup.
The term comes from a word meaning starch-like, describing the deposits' appearance when stained.
Greek nineteenth letter
- plaquesCommemorative mounted inscriptions
- tanglesKnotted, twisted masses
- dementiaChronic cognitive impairment
- neurodegenerationProgressive loss of neurons
cognitive · memory · hippocampus · atrophy · senile · neuritic · cholinesterase · biomarker
Improper protein conformation
- accumulationCollected mass over time
- depositsMaterial settled or stored
- plaquesCommemorative mounted inscriptions
- clumpingForming into lumps
assembly · nucleation · seeding · insoluble · precipitation · polymerization · self-assembly · cluster
Self-propagating rogue protein
- spongiformResembling a sponge's structure
- encephalopathyDisease impairing brain function
- scrapieOvine prion disease
- kuruPrion disease from cannibalism
transmissible · propagation · neurodegeneration · bovine · infectivity · strain
Pathological protein deposition disorder
- neuropathologyStudy of nervous system diseases
- neurotoxicityHarmful effects on nerves
- apoptosisProgrammed cell death
- inflammationProtective tissue response
deposition · systemic · organ · cardiac · renal · hepatic · spleen · biopsy
Folded amino chain
- polypeptideAmino acid polymer
- fibrilTiny structural thread
- precursorSomething that comes first
- APPProgram, abbreviated
cleavage · conformation · peptide · hydrophobic · tertiary · quaternary · proteolysis · fragment
tau
Greek nineteenth letter
- plaquesCommemorative mounted inscriptions
- tanglesKnotted, twisted masses
- dementiaChronic cognitive impairment
neurodegeneration · cognitive · memory · hippocampus · atrophy · senile · neuritic · cholinesterase · biomarker · PET
misfolding
Improper protein conformation
- accumulationCollected mass over time
- depositsMaterial settled or stored
- plaquesCommemorative mounted inscriptions
clumping · assembly · nucleation · seeding · insoluble · precipitation · polymerization · self-assembly · cluster · concentration
prion
Self-propagating rogue protein
- spongiformResembling a sponge's structure
- encephalopathyDisease impairing brain function
- scrapieOvine prion disease
kuru · transmissible · propagation · neurodegeneration · bovine · infectivity · strain
amyloidosis
Pathological protein deposition disorder
- neuropathologyStudy of nervous system diseases
- neurotoxicityHarmful effects on nerves
- apoptosisProgrammed cell death
inflammation · deposition · systemic · organ · cardiac · renal · hepatic · spleen · biopsy · tissue
protein
Folded amino chain
- polypeptideAmino acid polymer
- fibrilTiny structural thread
- precursorSomething that comes first
APP · cleavage · conformation · peptide · hydrophobic · tertiary · quaternary · proteolysis · fragment
- cell inclusionsinclusion bodies, ferritin, glycogen, melanin, Howell-Jolly bodies
- proteinsprotein, proteins, albumin, collagen, casein
- dementiamemory loss, Alzheimer's, forgetfulness, cognitive decline, memory impairment
- misfolded proteinsprion, tau, fibril, aggregate, tangle
- Proteinopathiesprions, Alzheimer's disease, amyloidosis, Parkinson's disease, aggregates
- neuroscienceneuron, MRI, brain, neurons, synapses