succinyl-CoA
Krebs pathway metabolite
Succinyl-CoA is a molecule central to cellular energy metabolism, formed during the citric acid cycle when alpha-ketoglutarate loses a carbon dioxide.
The high-energy bond between succinate and coenzyme A can be harvested to make GTP or ATP.
Succinyl-CoA also serves as a building block for synthesizing heme and other porphyrins.
Aerobic respiration's central pathway
- alpha-ketoglutarateTricarboxylic acid cycle metabolite
- GTPGuanine nucleotide triphosphate
- mitochondriaCell's energy-producing organelles
- cellular respirationCell-level fuel burning
acetyl-CoA · NADH · carbon dioxide · energy production · intermediate · metabolite · aerobic respiration · citrate
Simplest amino acid
- pyridoxal phosphateActive coenzyme of B6
- hemoglobinErythrocyte's oxygen-binding protein
- myoglobinMuscle's oxygen-binding protein
- cytochromeHeme protein transferring electrons
chlorophyll · bilirubin · erythrocyte · bone marrow · precursor · condensation · mitochondrial matrix
Group-moving enzyme
- ligaseBond-creating enzyme
- cofactorEnzyme-activating compound
- activationSetting into operation
- hydrolysisWater-induced bond cleavage
Inadequate cobalamin levels
- valineEssential branched-chain amino acid
- isoleucineEssential branched-chain amino acid
- methionineSulfur-bearing essential amino-acid
- threonineEssential amino acid
cobalamin · neurological symptoms · metabolic disorder · newborn screening · dietary restriction · supplementation
citric acid cycle
Aerobic respiration's central pathway
- alpha-ketoglutarateTricarboxylic acid cycle metabolite
- GTPGuanine nucleotide triphosphate
- mitochondriaCell's energy-producing organelles
cellular respiration · acetyl-CoA · NADH · carbon dioxide · energy production · intermediate · metabolite · aerobic respiration · citrate · malate
glycine
Simplest amino acid
- pyridoxal phosphateActive coenzyme of B6
- hemoglobinErythrocyte's oxygen-binding protein
- myoglobinMuscle's oxygen-binding protein
cytochrome · chlorophyll · bilirubin · erythrocyte · bone marrow · precursor · condensation · mitochondrial matrix
transferase
Group-moving enzyme
- ligaseBond-creating enzyme
- cofactorEnzyme-activating compound
- activationSetting into operation
vitamin B12 deficiency
Inadequate cobalamin levels
- valineEssential branched-chain amino acid
- isoleucineEssential branched-chain amino acid
- methionineSulfur-bearing essential amino-acid
threonine · cobalamin · neurological symptoms · metabolic disorder · newborn screening · dietary restriction · supplementation
- Heme Synthesisheme, porphobilinogen, uroporphyrinogen, glycine
- metabolitespyruvate, lactate, glucose, citrate, acetyl-CoA
- CofactorsNADH, FAD, biotin, thiamine, PLP
- Krebs Cyclecitrate, alpha-ketoglutarate, malate, acetyl-CoA, citric acid cycle
- Thioestersacetyl-CoA, acyl-CoA
- amino acidsalanine, arginine, asparagine, cysteine, glutamine
succinyl-CoAacetyl-CoA
Activated two-carbon metabolic intermediate
alpha-ketoglutarate · citrate · GTP · GDP