uroporphyrinogen
Uroporphyrinogen is a biochemical intermediate in the synthesis of heme and chlorophyll—ring-shaped molecules essential for oxygen transport in blood and photosynthesis in plants.
The body produces several types (I, III), with defects in their processing causing porphyrias, diseases marked by light sensitivity and other symptoms.
Iron-porphyrin complex in blood
- biosynthesisLiving production of molecules
- synthaseBond-forming enzyme
- porphobilinogenHeme biosynthesis intermediate
- precursorSomething that comes first
intermediate · enzyme · isomer · cytoplasm · mitochondria · substrate · catalysis · metabolite
Heme pathway enzyme disorder
- deficiencyLack of something needed
- accumulationCollected mass over time
- photosensitivityReactivity to radiant energy
- hepaticRelating to liver
blistering · urine · excretion · diagnosis · mutation · genetic · inherited · skin lesions
heme
Iron-porphyrin complex in blood
- biosynthesisLiving production of molecules
- synthaseBond-forming enzyme
- porphobilinogenHeme biosynthesis intermediate
precursor · intermediate · enzyme · isomer · cytoplasm · mitochondria · substrate · catalysis · metabolite · ring
porphyria
Heme pathway enzyme disorder
- deficiencyLack of something needed
- accumulationCollected mass over time
- photosensitivityReactivity to radiant energy
hepatic · blistering · urine · excretion · diagnosis · mutation · genetic · inherited · skin lesions · liver disease
- heme biochemistryheme, hemoglobin, globin, myoglobin, oxyhemoglobin
- Heme Synthesisheme, porphobilinogen, succinyl-CoA, glycine
- Porphyrinscoproporphyrin, heme, porphobilinogen
- metabolitespyruvate, lactate, glucose, citrate, acetyl-CoA
- bilirubinbilirubin, conjugated bilirubin, jaundice, neonatal jaundice
uroporphyrinogenheme
Iron-porphyrin complex in blood
hemoglobin · cytochrome · bilirubin · chlorophyll · cobalamin