pre-mRNA

Needs splicing still

Pre-mRNA is the initial RNA transcript produced when DNA is copied in a cell's nucleus, before it undergoes processing to become mature messenger RNA.

This precursor contains sequences called introns that will be spliced out, along with exons that will remain in the final mRNA.

The processing—splicing, capping, and adding a poly-A tail—must occur before the molecule can leave the nucleus and direct protein synthesis.

processing

splicing

Connecting by interweaving ends

intronNoncoding gene segment
exonProtein-coding gene segment
cappingSetting an upper limit

editing · maturation · lariat · cleavage · modification · nuclear · transcript · U2 · donor · acceptor

structure

intron

Noncoding gene segment

exonProtein-coding gene segment
heterogeneousConsisting of dissimilar elements
nucleotideGenetic code subunit

ribose · phosphate · adenine · guanine · cytosine · uracil · sequence · hairpin

regulation

developmental

Related to growth stages

enhancerAgent of improvement
silencerSound-dampening gun attachment
regulatoryInvolving official oversight

inclusion · exclusion · mutation · disease

research

sequencing

Determining element order

reporterOne who gathers news
in-vitroIn artificial environment
HeLaImmortal human cell line

knockdown · CRISPR · antisense · therapeutics

pre-mRNA

splicing

intron

developmental

sequencing

pre-mRNA

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