folate metabolism
Cellular B9 handling
Folate metabolism is the set of biochemical processes by which the body absorbs, converts, and uses folate (vitamin B9).
These reactions are essential for DNA synthesis, cell division, and amino acid processing.
Defects in folate metabolism—whether from dietary deficiency, genetic variants like MTHFR mutations, or drug interference—can cause anemia, neural tube defects in pregnancy, and elevated homocysteine levels.
- leafy greensEdible plant foliage
- folic acidB-vitamin preventing birth defects
- megaloblastic anemiaDefective red cell maturation
- neural tube defectsCNS formation abnormalities
- birth defectsAbnormalities present from delivery
fortified cereals · prenatal vitamins · healthy pregnancy · dietary intake · bioavailability · food fortification · cobalamin · B12 deficiency · methylation · cancer prevention · methionine · cognitive decline · immune function · methotrexate · coenzymes · DNA synthesis · supplements · spina bifida
- Biochemical Pathwaysglycolysis, citric acid cycle, Cori cycle, beta-oxidation, fatty acid synthesis
- nutrigenomicspolymorphisms, genotype, phenotype, caffeine sensitivity, gene expression
- Biosynthesisprotein synthesis, DNA synthesis, fatty acid synthesis, lipogenesis, hemoglobin synthesis
- Nucleotidesadenine, guanine, thymine, cytosine, uracil