amyloids
Misfolded protein aggregates
Amyloids are abnormal protein deposits that accumulate in body tissues, forming insoluble fibers with a distinctive structure.
These misfolded proteins clump together in ways the body cannot easily clear.
Amyloid buildup is associated with serious diseases—Alzheimer's involves amyloid plaques in the brain, while systemic amyloidosis affects organs like the heart and kidneys.
The brain scan showed significant amyloid accumulation.
Inscribed memorial tablet
- Alzheimer'sDegenerative brain disease
- dementiaChronic cognitive impairment
- neurodegenerationProgressive loss of neurons
- tanglesKnotted, twisted masses
spongiform · encephalopathy · prion · atrophy · parkinsonism · pathogenesis · neurotoxicity · cytotoxicity
Tiny structural thread
- misfoldingImproper protein conformation
- aggregationCombined collection of items
- polymerizationMonomers bonding into chains
- conformationStructural form or arrangement
self-assembly · insoluble · deposit · filamentous · nanofiber · morphology · macromolecular · crystalline
Folded amino chain
- polypeptideAmino acid polymer
- peptideShort amino acid chain
- amino acidsOrganic compounds forming proteins
- precursorSomething that comes first
APP · tau · chaperone · denaturation · biosynthesis · enzyme · cleavage
Seat of cognition
- neuronImpulse-conducting cell
- synapseNerve signal crossing point
- cerebralRelating to intellect
- cortexOrgan's external tissue
hippocampus · cognition · memory · neuropathology · cognitive · impairment · synaptic · microglia
Gradual functional decline with age
- gerontologyScientific study of senescence
- degenerationProgressive loss of function
- declineDecrease or refuse
- senilityAge-related mental decline
elderly · vulnerability · frailty · forgetfulness · age-related · progression
Measurable biological health signal
- diagnosisIdentification of illness
- imagingProducing visual representations
- PET scanRadiotracer-based internal imaging
- stainingApplying dye or pigment
immunotherapy · clinical trial · therapeutic · antibody · detection
plaque
Inscribed memorial tablet
- Alzheimer'sDegenerative brain disease
- dementiaChronic cognitive impairment
- neurodegenerationProgressive loss of neurons
tangles · spongiform · encephalopathy · prion · atrophy · parkinsonism · pathogenesis · neurotoxicity · cytotoxicity · senile
fibril
Tiny structural thread
- misfoldingImproper protein conformation
- aggregationCombined collection of items
- polymerizationMonomers bonding into chains
conformation · self-assembly · insoluble · deposit · filamentous · nanofiber · morphology · macromolecular · crystalline · extracellular
protein
Folded amino chain
- polypeptideAmino acid polymer
- peptideShort amino acid chain
- amino acidsOrganic compounds forming proteins
precursor · APP · tau · chaperone · denaturation · biosynthesis · enzyme · cleavage
brain
Seat of cognition
cortex · hippocampus · cognition · memory · neuropathology · cognitive · impairment · synaptic · microglia · astrocyte
senescence
Gradual functional decline with age
- gerontologyScientific study of senescence
- degenerationProgressive loss of function
- declineDecrease or refuse
senility · elderly · vulnerability · frailty · forgetfulness · age-related · progression
biomarker
Measurable biological health signal
- diagnosisIdentification of illness
- imagingProducing visual representations
- PET scanRadiotracer-based internal imaging
staining · immunotherapy · clinical trial · therapeutic · antibody · detection