N-acetyltransferase
Metabolizes certain drugs
N-acetyltransferase is an enzyme that transfers acetyl groups to other molecules, playing a key role in how the body metabolizes drugs and foreign compounds.
Genetic variations in N-acetyltransferase activity cause people to be "fast acetylators" or "slow acetylators," affecting how quickly they process certain medications and their susceptibility to drug side effects or toxicity.
Acetyl group attachment
- transferaseGroup-moving enzyme
- catalysisAccelerating reactions without consumption
- substrateUnderlying supporting material
- cofactorEnzyme-activating compound
active site · metabolite · conjugation · biotransformation · lysine · hydrazine
Malignancy of urine-storing organ
- detoxificationRemoving harmful substances internally
- bioactivationConversion to active form
- tobacco smokeCombusted leaf vapor
- anilineAmino-benzene compound
Body's chemical processing of medications
- polymorphismMany forms, one interface
- pharmacokineticsDrug fate in body
- hydralazineArterial relaxant for hypertension
- genotypeOrganism's complete allele set
phenotyping · personalized medicine · adverse reaction · toxicity · clearance
Many forms, one interface
- alleleGene variant at one locus
- genotypingAnalyzing DNA variants
- mutationPermanent DNA alteration
- haplotypeLinked genetic variants inherited together
genetic variation · inheritance · expression · sequencing · biomarker · promoter · deletion · recombinant
acetylation
Acetyl group attachment
- transferaseGroup-moving enzyme
- catalysisAccelerating reactions without consumption
- substrateUnderlying supporting material
cofactor · active site · metabolite · conjugation · biotransformation · lysine · hydrazine
bladder cancer
Malignancy of urine-storing organ
- detoxificationRemoving harmful substances internally
- bioactivationConversion to active form
- tobacco smokeCombusted leaf vapor
aniline · risk assessment · susceptibility · metabolic activation
drug metabolism
Body's chemical processing of medications
- polymorphismMany forms, one interface
- pharmacokineticsDrug fate in body
- hydralazineArterial relaxant for hypertension
genotype · phenotyping · personalized medicine · adverse reaction · toxicity · clearance
polymorphism
Many forms, one interface
- alleleGene variant at one locus
- genotypingAnalyzing DNA variants
- mutationPermanent DNA alteration
haplotype · genetic variation · inheritance · expression · sequencing · biomarker · promoter · deletion · recombinant · wild-type
- Drug Metabolismbiotransformation, drug metabolism, metabolite, metabolites, CYP450
- Metabolic EnzymesCYP450, CYP3A4, CYP2D6, GST, NAT