double-strand break
Both helices cut
A double-strand break is damage to DNA where both strands of the double helix are severed at the same location or nearby.
This is among the most serious forms of DNA damage—if unrepaired, it can lead to cell death or mutations that cause cancer.
Cells have repair mechanisms, but errors during repair can cause chromosomal rearrangements.
Radiation therapy kills cancer cells by inducing double-strand breaks.
- DNAHereditary code molecule
- DNA damageInjury to genetic material
- repairRestore to working order
- damageHarm or impairment
- chromosomeDNA strand carrying genes
recombination · CRISPR · gene editing · radiation · gamma rays · mutation · genome · nuclease · cleavage · ligase · cell · cell cycle · cancer · apoptosis · homologous · splicing · fracture · severed
- Gene EditingCRISPR, Cas9, CRISPR-Cas9, gene editing, HDR
- Genome IntegrityDNA repair, DNA damage, mutations, proofreading, error correction
- Recombinationrecombination, crossing over, crossover, recombinant, chiasma