pharmacogenomics
Personalized medicine foundation
Pharmacogenomics is the study of how genetic variation affects individual responses to drugs.
Some people metabolize medications faster or slower based on their genes; others may experience severe side effects that most people don't.
The field aims to tailor drug selection and dosage to a patient's genetic profile: Pharmacogenomics could make trial-and-error prescribing obsolete.
Controlled health research experiments
- GWASGenetic variant population analysis
- bioinformaticsComputational analysis of genetic data
- pharmacokineticsDrug fate in body
- data analysisSystematic information interpretation
drug development · molecular biology · biobank · drug discovery
Organism's complete allele set
- alleleGene variant at one locus
- polymorphismMany forms, one interface
- haplotypeLinked genetic variants inherited together
- mutationPermanent DNA alteration
chromosome · nucleotide · CYP2D6 · phenotype · genotyping · sequencing · heredity · locus
Treatment based on individual characteristics
- prescribingFormally ordering treatment
- treatment guidelinesRecommended care procedures
- pharmacotherapyTreatment using pharmaceutical agents
Cellular nutrient conversion
- efficacyAbility to produce results
- adverse reactionHarmful response to intervention
- dosage adjustmentChanging prescribed amount
- bioavailabilityFraction reaching active circulation
drug interaction · toxicity · side effects · drug sensitivity · treatment failure
Measurable biological health signal
- diagnosticTest to identify problems
- laboratoryFacility for scientific investigation
- direct-to-consumerSelling without retail intermediaries
clinical trials
Controlled health research experiments
- GWASGenetic variant population analysis
- bioinformaticsComputational analysis of genetic data
- pharmacokineticsDrug fate in body
data analysis · drug development · molecular biology · biobank · drug discovery
genotype
Organism's complete allele set
- alleleGene variant at one locus
- polymorphismMany forms, one interface
- haplotypeLinked genetic variants inherited together
mutation · chromosome · nucleotide · CYP2D6 · phenotype · genotyping · sequencing · heredity · locus · linkage
precision medicine
Treatment based on individual characteristics
- prescribingFormally ordering treatment
- treatment guidelinesRecommended care procedures
- pharmacotherapyTreatment using pharmaceutical agents
metabolism
Cellular nutrient conversion
- efficacyAbility to produce results
- adverse reactionHarmful response to intervention
- dosage adjustmentChanging prescribed amount
bioavailability · drug interaction · toxicity · side effects · drug sensitivity · treatment failure
biomarker
Measurable biological health signal
- diagnosticTest to identify problems
- laboratoryFacility for scientific investigation
- direct-to-consumerSelling without retail intermediaries
genetic, pharmacy, genetics, genome, genomics, geneticist, genomic, pharmacology, genomes