beta-amyloid
Dementia-linked protein fragment
Beta-amyloid is a protein fragment that accumulates in the brains of people with Alzheimer's disease, forming sticky plaques between nerve cells.
These clumps are believed to disrupt cell function and trigger the cognitive decline associated with the condition.
The term appears frequently in medical research and pharmaceutical contexts: The new drug targets beta-amyloid buildup.
Whether beta-amyloid plaques are a cause or symptom of Alzheimer's remains an active area of scientific investigation.
Short amino acid chain
- APPProgram, abbreviated
- cleavageTendency to split cleanly
- aggregationCombined collection of items
- misfoldingImproper protein conformation
protein · hydrophobic · fragment · amino acids · monomer · dimer · cascade · enzyme
Inscribed memorial tablet
- Alzheimer'sDegenerative brain disease
- neurodegenerationProgressive loss of neurons
- tauGreek nineteenth letter
- dementiaChronic cognitive impairment
tangles · senile · deposits · aggregation · neurotoxicity · cerebral · amyloidosis · brain
Measurable biological health signal
- PET scanRadiotracer-based internal imaging
- CSFNeural tissue buffer
- clinical trialHuman subject research experiment
- immunotherapyDisease treatment via body's defenses
antibody · clearance · transgenic · drug development · imaging · diagnosis · prevention · intervention
Impulse-conducting cell
- synapseNerve signal crossing point
- blood-brain barrierProtective cerebral filtration system
- clearancePermitted passage or approval
- degradationDecline in condition
homeostasis · soluble · extracellular · interstitial · metabolism · production · accumulation · balance
peptide
Short amino acid chain
- APPProgram, abbreviated
- cleavageTendency to split cleanly
- aggregationCombined collection of items
misfolding · protein · hydrophobic · fragment · amino acids · monomer · dimer · cascade · enzyme · processing
plaque
Inscribed memorial tablet
- Alzheimer'sDegenerative brain disease
- neurodegenerationProgressive loss of neurons
- tauGreek nineteenth letter
dementia · tangles · senile · deposits · aggregation · neurotoxicity · cerebral · amyloidosis · brain · lesions
biomarker
Measurable biological health signal
- PET scanRadiotracer-based internal imaging
- CSFNeural tissue buffer
- clinical trialHuman subject research experiment
immunotherapy · antibody · clearance · transgenic · drug development · imaging · diagnosis · prevention · intervention · vaccine
neuron
Impulse-conducting cell
- synapseNerve signal crossing point
- blood-brain barrierProtective cerebral filtration system
- clearancePermitted passage or approval
degradation · homeostasis · soluble · extracellular · interstitial · metabolism · production · accumulation · balance · regulation