scleroderma
Autoimmune tissue stiffening
Scleroderma is a chronic autoimmune disease that causes hardening and tightening of the skin and connective tissues.
The name means "hard skin." In localized forms, it affects only patches of skin; in systemic forms, it can damage internal organs including the lungs, heart, and kidneys.
She was diagnosed with scleroderma after noticing her fingers turning white in the cold.
Structural body protein
- scarringPermanent mark formation
- fibroblastsCollagen-producing connective tissue cells
- cytokinesImmune signaling proteins
- inflammationProtective tissue response
remodeling · biopsy · pathology · proliferation · stiffness · adhesions · fibrotic
Pathological calcium deposits
- dysphagiaMedical swallowing difficulty
- contracturesPermanent tissue shortening
- hyperpigmentationLocalized skin darkening condition
- depigmentationLoss of natural coloring
State of being constricted
- hardeningBecoming less soft
- indurationAbnormal tissue firmness
- hyperpigmentationLocalized skin darkening condition
- depigmentationLoss of natural coloring
salt-and-pepper · cutaneous · subcutaneous · atrophy · ulceration · pitting · edema · pruritus
Linked symptoms forming pattern
- systemicAffecting an entire structure
- localizedRestricted to one place
- diffuseSpread thinly throughout
- limitedRestricted in extent
autoimmune · diagnosis · prognosis · rheumatology · antibodies · juvenile
Favoring reform and innovation
- incurableCannot be healed
- lifelongLasting entire existence
- managementOrganizing and directing resources
- flare-upsSudden intensifications of trouble
remission · exacerbation · monitoring · symptomatic · palliative · immunosuppressants · prognosis · multidisciplinary
collagen
Structural body protein
- scarringPermanent mark formation
- fibroblastsCollagen-producing connective tissue cells
- cytokinesImmune signaling proteins
inflammation · remodeling · biopsy · pathology · proliferation · stiffness · adhesions · fibrotic
calcinosis
Pathological calcium deposits
- dysphagiaMedical swallowing difficulty
- contracturesPermanent tissue shortening
- hyperpigmentationLocalized skin darkening condition
tightness
State of being constricted
- hardeningBecoming less soft
- indurationAbnormal tissue firmness
- hyperpigmentationLocalized skin darkening condition
depigmentation · salt-and-pepper · cutaneous · subcutaneous · atrophy · ulceration · pitting · edema · pruritus · dryness
syndrome
Linked symptoms forming pattern
- systemicAffecting an entire structure
- localizedRestricted to one place
- diffuseSpread thinly throughout
limited · autoimmune · diagnosis · prognosis · rheumatology · antibodies · juvenile
progressive
Favoring reform and innovation
- incurableCannot be healed
- lifelongLasting entire existence
- managementOrganizing and directing resources
flare-ups · remission · exacerbation · monitoring · symptomatic · palliative · immunosuppressants · prognosis · multidisciplinary · disease-modifying
sclerodermaatrophy
Wasting from disuse
cellulitis · erysipelas · contact dermatitis · acute inflammation
sclerodermathin skin