phase II metabolism
Drug modification stage
Phase II metabolism is the second stage of drug processing in the body, where enzymes attach molecules to compounds—typically those already modified by phase I metabolism—making them water-soluble enough for excretion.
Common reactions include glucuronidation, sulfation, and acetylation.
The drug's slow phase II metabolism explained why it lingered in her system.
- conjugationVerb form variation system
- sulfationLead sulfate crystal accumulation
- acetylationAcetyl group attachment
- methylationAttaching a methyl group
- glutathioneSulfur-containing cellular antioxidant
detoxification · liver · liver enzymes · hepatocyte · excretion · water-soluble · biotransformation · enzyme · transferase · cytochrome · drug · toxin · clearance · water soluble · bile · kidney · polar · elimination
- Drug Metabolismbiotransformation, CYP450, conjugation, oxidation, detoxification
- liver functionsdetoxification, protein synthesis, bile salts, coagulation factors, biotransformation
phase, phases, phased, phasing, metabolic, metabolism, metabolisms, metabolize, metabolizes