host-guest chemistry
Supramolecular binding interactions
Host-guest chemistry is a branch of supramolecular chemistry studying how molecules bind together through non-covalent interactions.
The host is typically a larger molecule with a cavity or binding site; the guest is a smaller molecule that fits inside.
Crown ethers capturing metal ions and cyclodextrins encapsulating drug molecules are classic examples.
The field underlies molecular recognition, drug delivery, and sensor design.
- ligandMolecule that binds centrally
- hydrogen bondElectronegativity-based intermolecular attraction
- receptorSignal-receiving molecule
- affinityNatural liking or attraction
- chelationChemical metal-ion capture
selectivity · zeolite · catalysis · chirality · self-assembly · cavity · cage · substrate · capsule · binding · coordination · template · inclusion · intercalation · pocket · threading · nanotechnology · stereochemistry
- supramoleculesself-assembly, encapsulation, lariats, daisy chains, cages
- CheminformaticsSAR, fingerprinting, docking, virtual libraries, Schrodinger
- Macrocyclesheme, chlorophyll, cobalamin, vitamin B12, cyclosporin