frameshift mutation
Genetic sequence derailment
A frameshift mutation is a genetic alteration where nucleotides are inserted or deleted in numbers not divisible by three, throwing off the reading frame of the entire gene sequence that follows.
Since DNA is read in three-letter codons, adding or removing one or two nucleotides scrambles every subsequent codon, usually producing a nonfunctional protein.
The disease was traced to a frameshift mutation in a single gene.
pathogenic
Abnormality in inherited code
- Tay-SachsInherited lysosomal storage disorder
- cystic fibrosisGenetic disorder thickening mucus
- haploinsufficiencyLone working allele inadequate
- inherited diseaseCondition passed through generations
evolutionary
Inherited molecular differences
- natural selectionDifferential reproductive success
- genetic driftRandom allele frequency change
- selective pressureInfluence favoring certain traits
genetic disorder
Abnormality in inherited code
- Tay-SachsInherited lysosomal storage disorder
- cystic fibrosisGenetic disorder thickening mucus
- haploinsufficiencyLone working allele inadequate
genetic variation
Inherited molecular differences
- natural selectionDifferential reproductive success
- genetic driftRandom allele frequency change
- selective pressureInfluence favoring certain traits
translation error
Flawed rendering between languages
- geneticsDNA, allele, genotype, genes, gene
- Cell ErrorsDNA damage, frameshift, translocation, inversion, transcription error
- DNA damageDNA damage, lesion, nick, mismatch, adduct
- Genetic Mutationsmutagenesis, nonsense, frameshift, deletion, insertion
- reading framesframeshift, codon, triplet
- translationtranslator, literal translation, literary translation, free translation, French translation