aromatase
Estrogen synthesis enzyme
Aromatase is an enzyme that converts androgens (male hormones) into estrogens (female hormones).
It plays a central role in estrogen production throughout the body.
Aromatase inhibitors are drugs that block this conversion, used primarily to treat hormone-sensitive breast cancer in postmenopausal women: She was prescribed an aromatase inhibitor after her mastectomy.
Primary natural estrogen hormone
- estroneA natural estrogen
- testosteroneChief male sex hormone
- conversionAct of changing states
- feminizationAcquiring female characteristics
biosynthesis · receptor · hormonal · breast · ovary · placenta · adipose · gynecology
Heme protein transferring electrons
- synthaseBond-forming enzyme
- proteinFolded amino chain
- catalystAgent enabling change
- active siteEnzyme region binding substrates
cofactor · substrate · inhibitor · biosynthesis · conversion · reaction · mechanism · kinetics
Malignant growth in mammary glands
- tumorAbnormal tissue mass
- antiestrogenCompound blocking estrogen activity
- tamoxifenAnti-estrogen cancer medication
- adjuvantImmunity-boosting additive
postmenopausal · recurrence · metastatic · chemoprevention · prognosis · remission · survival · clinical trial
Masculinizing steroid hormones
- estrogensFemale sex hormones
- hypothalamusSubthalamic regulatory brain region
- pituitaryBrain-base hormone gland
- gonadalConcerning reproductive glands
adrenal · ovarian · testicular · adipose · regulation · feedback · homeostasis · secretion
Lacking certain hormone-derived compounds
- steroidalOf certain hormones
- competitiveDriven by rivalry
- irreversibleCannot be undone
- pharmacologyStudy of drug actions
potency · selectivity · resistance · therapy · treatment · dosage · efficacy
estradiol
Primary natural estrogen hormone
- estroneA natural estrogen
- testosteroneChief male sex hormone
- conversionAct of changing states
feminization · biosynthesis · receptor · hormonal · breast · ovary · placenta · adipose · gynecology · puberty
cytochrome
Heme protein transferring electrons
active site · cofactor · substrate · inhibitor · biosynthesis · conversion · reaction · mechanism · kinetics · gene
breast cancer
Malignant growth in mammary glands
- tumorAbnormal tissue mass
- antiestrogenCompound blocking estrogen activity
- tamoxifenAnti-estrogen cancer medication
adjuvant · postmenopausal · recurrence · metastatic · chemoprevention · prognosis · remission · survival · clinical trial
androgens
Masculinizing steroid hormones
- estrogensFemale sex hormones
- hypothalamusSubthalamic regulatory brain region
- pituitaryBrain-base hormone gland
gonadal · adrenal · ovarian · testicular · adipose · regulation · feedback · homeostasis · secretion · expression
nonsteroidal
Lacking certain hormone-derived compounds
- steroidalOf certain hormones
- competitiveDriven by rivalry
- irreversibleCannot be undone
pharmacology · potency · selectivity · resistance · therapy · treatment · dosage · efficacy
aromatasearomatase inhibitors
Enzyme-blocking hormonal medications
- aromatase inhibitorsEnzyme-blocking hormonal medications