AZT
Early AIDS treatment
AZT is the abbreviation for azidothymidine, the first drug approved to treat HIV/AIDS.
Developed in the 1980s, it works by inhibiting the virus's ability to replicate.
AZT remains part of combination therapies for HIV, though newer drugs have largely supplanted it as a first-line treatment: He started on AZT in 1987.
Drug blocking viral reproduction
- AIDSImmune deficiency syndrome
- retrovirusRNA virus copying into DNA
- CD4Immune cell coreceptor
- T-cellsThymus-matured immune lymphocytes
nucleoside · inhibitor · monotherapy · mutation · adherence · prophylaxis · PrEP · transmission
Late twentieth-century year
- activismDirect effort for reform
- accessRight to enter
- pricingEstablishing monetary amounts charged
- breakthroughSudden important advance
Thymine-containing DNA nucleoside
- bioavailabilityFraction reaching active circulation
- half-lifePeriod for fifty-percent reduction
- metabolismCellular nutrient conversion
- dosageMeasured medicine amount
tablet · capsule · prescription · oral · intravenous · generic · brand-name · pharmaceutical
Red cell deficiency
- neutropeniaInsufficient neutrophils in blood
- myopathyDisorder of muscle tissue
- nauseaPre-vomiting stomach discomfort
- headacheCranial pain
fatigue · toxicity · mitochondrial · neuropathy · insomnia · malaise
antiretroviral
Drug blocking viral reproduction
- AIDSImmune deficiency syndrome
- retrovirusRNA virus copying into DNA
- CD4Immune cell coreceptor
T-cells · nucleoside · inhibitor · monotherapy · mutation · adherence · prophylaxis · PrEP · transmission · pandemic
1987
Late twentieth-century year
thymidine
Thymine-containing DNA nucleoside
- bioavailabilityFraction reaching active circulation
- half-lifePeriod for fifty-percent reduction
- metabolismCellular nutrient conversion
dosage · tablet · capsule · prescription · oral · intravenous · generic · brand-name · pharmaceutical · formulation
anemia
Red cell deficiency
- neutropeniaInsufficient neutrophils in blood
- myopathyDisorder of muscle tissue
- nauseaPre-vomiting stomach discomfort
headache · fatigue · toxicity · mitochondrial · neuropathy · insomnia · malaise
- HIV AntiviralsFTC
- Medicinespill, tablet, aspirin, tablets, penicillin
- HIV/AIDSHIV, AIDS, AIDS crisis, AIDS quilt, antiretrovirals
- nucleoside analogsacyclovir, valacyclovir, 5-fluorouracil, remdesivir
- Antiviralsacyclovir, valacyclovir, antiviral cream, amantadine, remdesivir
AZTplacebo
Inactive therapeutic substitute
cure · sugar pill · eradication · snake oil · quack remedy
AZTHIV
AIDS-causing retrovirus
AIDS · poison · pathogen · immunodeficiency · HIV transmission