antinociceptive
Reduces pain perception
Antinociceptive describes something that reduces or blocks the perception of pain.
The term appears in medical and pharmacological contexts: The drug showed antinociceptive effects in animal studies.
Nociception is the nervous system's detection of harmful stimuli; antinociceptive agents interfere with this process before pain registers consciously.
Absence of sensation
- numbingCausing loss of sensation
- soothingReducing distress or discomfort
- palliativeOffering relief, not remedy
- sedationDrug-induced calm state
calming · easing · alleviating · mitigating · suppressing · dulling · desensitizing · blunting
Brain's extension through vertebrae
- afferentConveying toward central point
- substance PPain-signaling neuropeptide
- somatosensoryRelating to bodily sensation
- thalamusBrain's signal switchboard
brainstem · peripheral nerves · neurotransmitters · synapse · neuroplasticity · axon · neuralgia · neuropathy
Body's innate pain blockers
- morphineOpioid analgesic medication
- fentanylSynthetic pain-blocking compound
- oxycodonePowerful prescription pain reliever
- buprenorphinePartial agonist for dependency
naloxone · naltrexone · tolerance · dependence · withdrawal · euphoria · methadone · hydrocodone
Signal-receiving molecule
- agonistReceptor-binding trigger molecule
- antagonistOne who opposes another
- modulationVarying signals to transmit
- affinityNatural liking or attraction
inhibition · dose-response · bioavailability · efficacy · potency · half-life · cannabinoid · adenosine
Compositional evaluation procedure
- animal modelSpecies used for research
- thresholdPoint of beginning
- latencyDelay in system response
- behavioralRelating to conduct
screening · compound · derivative · novel · efficacy · preclinical · in vivo · in vitro
analgesia
Absence of sensation
- numbingCausing loss of sensation
- soothingReducing distress or discomfort
- palliativeOffering relief, not remedy
sedation · calming · easing · alleviating · mitigating · suppressing · dulling · desensitizing · blunting · relieving
spinal cord
Brain's extension through vertebrae
- afferentConveying toward central point
- substance PPain-signaling neuropeptide
- somatosensoryRelating to bodily sensation
thalamus · brainstem · peripheral nerves · neurotransmitters · synapse · neuroplasticity · axon · neuralgia · neuropathy · wind-up
endorphins
Body's innate pain blockers
- morphineOpioid analgesic medication
- fentanylSynthetic pain-blocking compound
- oxycodonePowerful prescription pain reliever
buprenorphine · naloxone · naltrexone · tolerance · dependence · withdrawal · euphoria · methadone · hydrocodone · tramadol
receptor
Signal-receiving molecule
- agonistReceptor-binding trigger molecule
- antagonistOne who opposes another
- modulationVarying signals to transmit
affinity · inhibition · dose-response · bioavailability · efficacy · potency · half-life · cannabinoid · adenosine · prostaglandin
assay
Compositional evaluation procedure
- animal modelSpecies used for research
- thresholdPoint of beginning
- latencyDelay in system response
behavioral · screening · compound · derivative · novel · efficacy · preclinical · in vivo · in vitro