SNRI

Dual reuptake inhibitor

SNRI stands for serotonin-norepinephrine reuptake inhibitor, a class of antidepressant medications that increase levels of both serotonin and norepinephrine in the brain.

Common SNRIs include venlafaxine (Effexor) and duloxetine (Cymbalta).

They're prescribed for depression, anxiety disorders, and chronic pain conditions.

My doctor switched me from an SSRI to an SNRI.

pharmacology

reuptake

Neurotransmitter recapture by neurons

prescription · dosage · titration · discontinuation · withdrawal · tapering · half-life · metabolite · generic · brand

mechanism

norepinephrine

Alertness and stress hormone

neurotransmitter · receptor · binding · affinity · selectivity · neurochemistry · synaptic · cleft · presynaptic · modulation

treatment

depression

Prolonged low state

panic · stress · remission · response · efficacy · augmentation · monotherapy · first-line · second-line · off-label

side-effects

nausea

Pre-vomiting stomach discomfort

sweating · constipation · fatigue · hypertension · tremor · tolerance · adjustment

Opposites
pharmacological mechanism

SNRIMAOI

Enzyme-inhibiting psychiatric medication

dopamine antagonist · placebo · SSRI · beta-blocker · benzodiazepine

treatment approach

SNRIcognitive behavioral therapy

Treatment restructuring harmful thought patterns

psychotherapy · talk therapy · electroconvulsive therapy · exercise therapy · CBT

Family

serotonin

Familiarity
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