thalassaemia
Inherited anemia condition
Thalassaemia is a hereditary blood disorder in which the body produces abnormal hemoglobin, leading to anemia.
The condition ranges from mild to severe; major forms require regular blood transfusions.
It occurs most commonly in people of Mediterranean, Middle Eastern, African, and Southeast Asian descent.
Also spelled thalassemia.
Permanent DNA alteration
- inheritanceProperty received from ancestors
- carrierOne that transports
- hydrops fetalisAbnormal fluid in unborn
- genetic counselingGuidance on inherited conditions
prenatal diagnosis · consanguinity · pedigree · genotype · silent carrier · deletion · point mutation
Transfer of blood intravenously
- splenectomySurgical organ removal
- bone marrow transplantInfusing healthy hematopoietic cells
- stem cell transplantInfusion of blood-forming precursors
- gene therapyMedical DNA modification treatment
folic acid · ferritin · blood bank · matched donor · supportive care
Balkan peninsula nation
- ItalyBoot-shaped European nation
- CyprusMediterranean island nation
- SardiniaItalian autonomous island region
- SicilyMediterranean's biggest island
Crete · Malta · Middle East · Southeast Asia · South Asia · selective pressure · migration patterns · consanguinity
Erythrocyte's oxygen-binding protein
- erythrocytesOxygen-carrying blood cells
- hemolysisRed blood cell destruction
- red blood cellsOxygen-transporting components of circulation
- hematopoiesisBlood cell production process
Weariness from prolonged exertion
- weaknessDeficiency in force
- pallorUnhealthy facial whiteness
- shortness of breathDifficulty inhaling enough air
- dizzinessUnsteady, spinning sensation
heart palpitations · jaundice · bone deformities · hepatomegaly · osteoporosis · leg ulcers · gallstones · delayed puberty
mutation
Permanent DNA alteration
- inheritanceProperty received from ancestors
- carrierOne that transports
- hydrops fetalisAbnormal fluid in unborn
genetic counseling · prenatal diagnosis · consanguinity · pedigree · genotype · silent carrier · deletion · point mutation
transfusion
Transfer of blood intravenously
- splenectomySurgical organ removal
- bone marrow transplantInfusing healthy hematopoietic cells
- stem cell transplantInfusion of blood-forming precursors
gene therapy · folic acid · ferritin · blood bank · matched donor · supportive care
Greece
Balkan peninsula nation
- ItalyBoot-shaped European nation
- CyprusMediterranean island nation
- SardiniaItalian autonomous island region
Sicily · Crete · Malta · Middle East · Southeast Asia · South Asia · selective pressure · migration patterns · consanguinity
hemoglobin
Erythrocyte's oxygen-binding protein
- erythrocytesOxygen-carrying blood cells
- hemolysisRed blood cell destruction
- red blood cellsOxygen-transporting components of circulation
fatigue
Weariness from prolonged exertion
- weaknessDeficiency in force
- pallorUnhealthy facial whiteness
- shortness of breathDifficulty inhaling enough air
dizziness · heart palpitations · jaundice · bone deformities · hepatomegaly · osteoporosis · leg ulcers · gallstones · delayed puberty