reductive amination
Carbonyl-to-amine conversion
Reductive amination is a chemical reaction that converts a carbonyl compound (aldehyde or ketone) into an amine by combining it with ammonia or an amine in the presence of a reducing agent.
The process forms a carbon-nitrogen bond through an imine intermediate, which is then reduced to the final amine product.
It's a workhorse reaction in organic synthesis and pharmaceutical manufacturing for building nitrogen-containing molecules.
- amineAmmonia-derived organic compound
- aldehydeCarbonyl bonded to hydrogen
- ketoneCarbonyl between two carbons
- catalystAgent enabling change
- hydrogenationBonding hydrogen to compounds
nitrogen · carbonyl · enzyme · synthesis · organic chemistry · transaminase · cofactor · substrate · condensation · intermediate · pharmaceutical · chiral · stereochemistry · palladium · hydrogen · workbench · flask · fume hood
- Aminationtransamination
- Reductionredox, hydrogenation, deoxygenation
- derivatizationacetylation, methylation, esterification, alkylation, phosphorylation
reductive aminationtransamination
Amino group biochemical exchange
reductive aminationdeamination
Amino group removal process
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