pepsinogen

Pepsin's inactive form

Pepsinogen is an inactive precursor protein produced in the stomach lining.

When exposed to stomach acid, it converts to pepsin, the enzyme that breaks down proteins during digestion.

This activation mechanism prevents the enzyme from digesting the stomach's own tissues before reaching food.

zymogen

proenzyme

Inactive enzyme precursor

chymotrypsinogen · prohormone · conversion · signal peptide

gastric

hydrochloric acid

Corrosive hydrogen chloride solution

gastric juice · stomach lining · secretion · exocrine · gastrin

proteolysis

cleavage

Tendency to split cleanly

substrate · denaturation · catalysis

clinical

H. pylori

Stomach-dwelling spiral bacterium

Opposites
activation state

pepsinogenpepsin

Gastric protein-cleaving enzyme

protease · trypsin

Family

dyspepsia, pepsin, peptic, peptidase

Familiarity
Top 1,000,000
Profile
Used worldwide · Timeless · Concrete · Rated G