G6PD deficiency
Favism-causing genetic condition
G6PD deficiency is a genetic condition in which red blood cells lack sufficient glucose-6-phosphate dehydrogenase, an enzyme that protects them from oxidative damage.
Certain foods (especially fava beans), infections, or medications can trigger episodes of hemolytic anemia—rapid destruction of red blood cells.
The condition is X-linked, affecting males more severely, and is most common in people of African, Mediterranean, and Asian descent.
- fava beansLarge, flat edible legumes
- broad beansLarge edible legume seeds
- mutationPermanent DNA alteration
- sulfa drugsSynthetic antibacterial compounds
- jaundiceYellowing from bile pigment
enzyme · naphthalene · dark urine · aspirin · infections · red blood cells · antimalarials · drug reaction · hemoglobin · newborn screening · pallor · metabolic disorder · mothballs · fatigue · thalassemia · sickle cell anemia · glucose · bilirubin
- Anemiahemoglobin, low hemoglobin, low iron, pernicious anemia, sickle cell
- Genetic Disorderscystic fibrosis, hemophilia, sickle cell disease, sickle cell anemia, sickle cell
- blood disordersanemia, sickle cell anemia, sickle cell disease, thalassemia, leukemia
- Metabolic DisordersPKU, Tay-Sachs disease, Tay-Sachs, Niemann-Pick disease, Krabbe disease
- X-linked geneticsX chromosome, hemophilia, color blindness, colorblindness, red-green blindness
- Anemiassickle cell anemia, pernicious anemia, megaloblastic anemia, thalassemia, sideroblastic anemia
deficiency, deficient, deficiently, deficit, defect, defective, defection, sufficient, sufficiency