Sonogashira coupling
Palladium-catalyzed alkyne bonding
Sonogashira coupling is a chemical reaction that joins a terminal alkyne to an aryl or vinyl halide, forming a carbon-carbon bond.
The reaction uses palladium and copper catalysts and is fundamental in organic synthesis for building complex molecules: The researchers used Sonogashira coupling to construct the drug's aromatic backbone.
- transmetalationIntercompound atomic exchange
- terminal alkyneTriple bond at chain's end
- alkyneTriple-bonded carbon compound
- oxidative additionMetal cleaves and binds substrate
- C-H activationDirect modification of hydrocarbon bonds
copper · cyclization · phosphine · conjugated · acetylene · Suzuki · ligand · synthesis · glassware · catalyst · fume hood · bromide · iodide · base · aromatic · pharmaceutical · organic chemistry · triple bond
- Named ReactionsDiels-Alder reaction, Claisen condensation, Sandmeyer reaction
- Alkynesacetylene, alkyne, triple bond, terminal alkyne, sp hybridization
cross-coupling reaction type
Sonogashira couplingNegishi coupling
Organozinc palladium cross-linking method